N',N'-diethyl-N-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine
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N',N'-diethyl-N-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine
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CAS No:
57695-04-2
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Formula:
C21H33N3O
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Chemical Name:
N',N'-diethyl-N-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine
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Synonyms:
8-((6-(diethylamino)hexyl)amino)-6-methoxy-4-methylquinoline;8-(6-diethylaminohexylamino)-6-methoxy-4-methylquinoline dihydrochloride;8-aminoquinoline;8-quinolinamine;N,N-diethyl-N'-(6-methoxy-4-methyl-8-quinolinyl)-1,6- hexanediamine;sitamaquine;WR 006026;WR 6026;WR-006026;WR-6026;WR006026;WR6026;Sitamaquine;57695-04-2;WR6026;UNII-5AIJ4TGC6B;WR-6026;5AIJ4TGC6B;WR 6026;WR 6026 dihydrochloride;MMV000063;1,6-Hexanediamine, N,N-diethyl-N'-(6-methoxy-4-methyl-8-quinolinyl)-;NSC2452;Sitamaquine [INN:BAN];5330-29-0;DRG-0140;WR 006026;CHEMBL57004;SCHEMBL1070741;6-Methoxy-8-(6-diethylaminohexylamino)-4-methylquinoline;DTXSID70206395;8-((6-(Diethylamino)hexyl)amino)-6-methoxy-4-methylquinoline;BCP07171;ZINC1535009;N',N'-diethyl-N-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine;N,N-Diethyl-N'-(6-methoxy-4-methyl-8-quinolyl)hexane-1,6-diamine;2,5-DIMETHOXY-4-NITROSTILBENE;DB04909;NCGC00386990-01;SR-05000022548;SR-05000022548-1;Q27095559;N',N'-diethyl-N-(6-methoxy-4-methyl-8-quinolyl)hexane-1,6-diamine;N,N-Diethyl-N'-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine;SITAMAQUINE,N,N-DIETHYL-N'-(6-METHOXY-4-METHYL-QUINOLIN-8-YL)-HEXANE-1,6-DIAMINE
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CAS No:
Description
Sitamaquine (WR-6026) is an orally active 8-aminoquinoline analog in development by the Walter Reed Army Institute, in collaboration with GlaxoSmithKline (formerly SmithKline Beecham), for the potential treatment of visceral leishmaniasis.
N',N'-diethyl-N-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine Basic Attributes
343.5 g/mol
343.262362685 g/mol
226-224-0
5AIJ4TGC6B
DTXSID70206395
Safety Information
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P310, P302+P352, P305+P351+P338, P310, P321, P330, P333+P313, P363, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Investigated for use/treatment in infectious and parasitic disease (unspecified).
The mechanism of plasmodicidal action of sitamaquine is not completely understood. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites.
8-((6-(diethylamino)hexyl)amino)-6-methoxy-4-methylquinoline
Computed Properties
Molecular Weight:343.5
XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:11
Exact Mass:343.262362685
Monoisotopic Mass:343.262362685
Topological Polar Surface Area:37.4
Heavy Atom Count:25
Complexity:348
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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