(2S)-2-[[4-[2-(2,4-diaminopteridin-6-yl)ethyl]benzoyl]amino]pentanedioic acid
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![(2S)-2-[[4-[2-(2,4-diaminopteridin-6-yl)ethyl]benzoyl]amino]pentanedioic acid structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/d794f14dde5f4534bc4e75fb7021ddd6.png "(2S)-2-[[4-[2-(2,4-diaminopteridin-6-yl)ethyl]benzoyl]amino]pentanedioic acid")
(2S)-2-[[4-[2-(2,4-diaminopteridin-6-yl)ethyl]benzoyl]amino]pentanedioic acid
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CAS No:
52454-37-2
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Formula:
C20H21N7O5
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Chemical Name:
(2S)-2-[[4-[2-(2,4-diaminopteridin-6-yl)ethyl]benzoyl]amino]pentanedioic acid
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Synonyms:
10-deaza-aminopterin;10-deazaaminopterin;10-deazaaminopterin hydrochloride;10-deazaaminopterin monohydrochloride;10-deazaaminopterin, sodium salt;10-deazaminopterin;10-Deazaaminopterin;GNF-PF-173;UNII-PXJ16PPE04;52454-37-2;PXJ16PPE04;CHEMBL293263;10-Deazaminopterin;10-Deaza-aminopterin;(4-(2-(2,4-diaminopteridin-6-yl)ethyl)benzoyl)-L-glutamic acid;NSC 311469;10-DAM;SCHEMBL7081697;BDBM50016461;L-Glutamic acid, N-(4-(2-(2,4-diamino-6-pteridinyl)ethyl)benzoyl)-;(2S)-2-[[4-[2-(2,4-diaminopteridin-6-yl)ethyl]benzoyl]amino]pentanedioic acid;Q27286805;(S)-2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
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CAS No:
(2S)-2-[[4-[2-(2,4-diaminopteridin-6-yl)ethyl]benzoyl]amino]pentanedioic acid Basic Attributes
439.4 g/mol
439.16041680 g/mol
PXJ16PPE04
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Folic Acid Antagonists.)
10-deaza-aminopterin
Computed Properties
Molecular Weight:439.4
XLogP3:-1.3
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:9
Exact Mass:439.16041680
Monoisotopic Mass:439.16041680
Topological Polar Surface Area:207
Heavy Atom Count:32
Complexity:673
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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