Fluasterone
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Fluasterone
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CAS No:
112859-71-9
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Formula:
C19H27FO
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Chemical Name:
Fluasterone
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Synonyms:
Androst-5-en-17-one,16-fluoro-,(16α)-;(16α)-16-Fluoroandrost-5-en-17-one;16α-Fluoro-5-androsten-17-one;Fluasterone;156680-74-9
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CAS No:
Drug Information
Investigated for use/treatment in psoriasis and psoriatic disorders, hyperlipidemia, metabolic disease, cancer/tumors (unspecified), and obesity.
Fluasterone is a synthetically stable adrenocortical steroid fluorinated analogue of dehydroepiandrosterone (DHEA), a powerful anti-inflammatory molecule with androgenic or estrogenic side effects. It is proposed that fluasterone inhibits NF-kB activation and reduces oxidative stress, but other mechanisms may play a role. Fluasterone suppresses inflammation and is effective in preclinical models of chronic inflammatory disease including psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and lupus erythematosus. Fluasterone has anti-inflammatory effects inpreclinical models of chronic inflammatory disease including psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and lupus erythematosus. [Aeson Pharmaceuticals Executive Report]
5-androstene-16-fluoro-17-one
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