disodium;4-amino-1-[(2S)-3-hydroxy-2-(phosphonatomethoxy)propyl]pyrimidin-2-one
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![disodium;4-amino-1-[(2S)-3-hydroxy-2-(phosphonatomethoxy)propyl]pyrimidin-2-one structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/85b9a1133b904d519dc16dd28209af0e.png "disodium;4-amino-1-[(2S)-3-hydroxy-2-(phosphonatomethoxy)propyl]pyrimidin-2-one")
disodium;4-amino-1-[(2S)-3-hydroxy-2-(phosphonatomethoxy)propyl]pyrimidin-2-one
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CAS No:
127749-27-3
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Formula:
C8H12N3Na2O6P
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Chemical Name:
disodium;4-amino-1-[(2S)-3-hydroxy-2-(phosphonatomethoxy)propyl]pyrimidin-2-one
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Synonyms:
1-((3-hydroxy-2-phosphonylmethoxy)propyl)cytosine;1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine;cidofovir;cidofovir anhydrous;cidofovir sodium;cidofovir, (+-)-isomer;cidofovir, (R)-isomer;cidofovir, sodium salt;GS 504;GS-504;GS504;HPMPC;Vistide;Cidofovir sodium;UNII-M83JB37U61;M83JB37U61;Cidofovir disodium;120362-37-0;127749-27-3;Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, disodium salt, (S)-;Q27283611;Sodium (S)-(((1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate
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CAS No:
Description
An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.
disodium;4-amino-1-[(2S)-3-hydroxy-2-(phosphonatomethoxy)propyl]pyrimidin-2-one Basic Attributes
323.15 g/mol
323.02591067 g/mol
M83JB37U61
Drug Information
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
1-((3-hydroxy-2-phosphonylmethoxy)propyl)cytosine
Computed Properties
Molecular Weight:323.15
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:323.02591067
Monoisotopic Mass:323.02591067
Topological Polar Surface Area:151
Heavy Atom Count:20
Complexity:406
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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