6-hydroxy-14-[2-(2-hydroxyethylamino)ethyl]-10-[2-(2-hydroxyethylamino)ethylamino]-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-8-one;hydrate;tetrahydrochloride
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![6-hydroxy-14-[2-(2-hydroxyethylamino)ethyl]-10-[2-(2-hydroxyethylamino)ethylamino]-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-8-one;hydrate;tetrahydrochloride structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/a96bcbd5b71c434fbb96a35f981b1280.png "6-hydroxy-14-[2-(2-hydroxyethylamino)ethyl]-10-[2-(2-hydroxyethylamino)ethylamino]-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-8-one;hydrate;tetrahydrochloride")
6-hydroxy-14-[2-(2-hydroxyethylamino)ethyl]-10-[2-(2-hydroxyethylamino)ethylamino]-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-8-one;hydrate;tetrahydrochloride
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CAS No:
132937-89-4
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Formula:
C44H60Cl4N10O9
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Chemical Name:
6-hydroxy-14-[2-(2-hydroxyethylamino)ethyl]-10-[2-(2-hydroxyethylamino)ethylamino]-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-8-one;hydrate;tetrahydrochloride
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Synonyms:
UNII-W6E275IURX;W6E275IURX;losoxantrone hydrochloride hydrate;Losoxantrone hydrochloride [USAN];132937-89-4;Losoxantrone hydrochloride (USAN);NSC-357885;DTXSID70157873;D04783;Q27292392;7-Hydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-((2-hydroxyethyl)amino)ethyl)amino)anthra(1,9-cd)pyrazol-6(2H)-one, dihydrochloride, hemihydrate;Anthra(1,9-cd)pyrazol-6(2H)-one, 7-hydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-, dihydrochloride, hydrate (2:1)
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CAS No:
Description
Losoxantrone Hydrochloride is the hydrochloride salt form of losoxantrone, an anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Losoxantrone is less cardiotoxic than doxorubicin.
6-hydroxy-14-[2-(2-hydroxyethylamino)ethyl]-10-[2-(2-hydroxyethylamino)ethylamino]-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-8-one;hydrate;tetrahydrochloride Basic Attributes
1014.8 g/mol
1014.326934 g/mol
W6E275IURX
DTXSID70157873
C72077
Computed Properties
Molecular Weight:1014.8
Hydrogen Bond Donor Count:17
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:22
Exact Mass:1014.326934
Monoisotopic Mass:1012.329884
Topological Polar Surface Area:264
Heavy Atom Count:67
Complexity:596
Covalently-Bonded Unit Count:7
Compound Is Canonicalized:Yes
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