Tetrasodium pyrophosphate

265.9

265.871002

231-767-1

O352864B8Z

1140

DTXSID9042465

CRYSTALS|COLORLESS, TRANSPARENT CRYSTALS OR WHITE POWDER|White powder or granules.

28353990

136

0.94120

White Granular

2.534 g/cm³

988 °C

93.8 °C

INDEX OF REFRACTION: 1.450, 1.453, 1.460 /DECAHYDRATE/|INDEX OF REFRACTION: 1.425

soluble in water. Insoluble in ethyl alcohol.H2O: 0.1 M at 20 °C, clear, colorless

Store at room temperature.

0 mmHg (approx)

Noncombustible Solid

Odorless.

Between 9,8 and 10,8 (1 % solution)

AVAIL ALKALINITY AS NA2O 4.4%, TOTAL ALKALINITY 22.7%|MP: 79.5 °C; DENSITY: 1.82; PH OF 1% SOLN: 10.2 @ 25 °C /DECAHYDRATE/|HYDROLYZES TO ORTHOPHOSPHATE IN AQ SOLN, BUT RATE OF HYDROLYSIS IS MUCH SLOWER THAN FOR MORE ACID PYROPHOSPHATE; NO NOTICEABLE HYDROLYSIS WITHIN 60 HR AT 70 °C

No rapid reaction with air No rapid reaction with water

Anhydrides

TETRASODIUM PYROPHOSPHATE is basic. Reacts exothermically with acids. Incompatible with strong oxidizing agents. Decomposes in ethyl alcohol.

Noncombustible Solid

Ⅱ

1759

3

36/37/38-41-22

26-36-39

UX7350000

Xi,Xn

Stable. Incompatible with strong oxidizing agents.

P280-P305 + P351 + P338

H302-H318

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Strong acids.

Tetrasodium pyrophosphate used as a sequestrant in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.|Tetrasodium pyrophosphate used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H302 (51.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 1556 companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501

In case of fire in the surroundings, use appropriate extinguishing media.

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premise. Provide: Eyewash fountains should be provided (when chemical is in solution) in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. (NIOSH, 2016)|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|Eyewash fountains should be provided in areas where there is any possbility that workers could be exposed to solutions containing the substance; this is irrespective of the recommendation involving the wearing of eye protection. /Solution/|(See protection codes)

The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet or significantly contaminated should be removed and replaced.|Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 mg/cu m.

Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.

Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly , especially if powdered.

The substance is irritating to the eyes, skin and respiratory tract.

PREVENT DISPERSION OF DUST!

Use ventilation (not if powder).

Protective gloves.

Wear safety spectacles.

IDENTIFICATION AND USE: This chemical is a colorless, transparent crystals or white powder or granules. It is odorless; slightly soluble in water; insoluble in alcohol and ammonia. This chemical is used as a cleaning compound; oil well drilling; water treatment, cheese emulsification; as a general sequestering agent, to remove rust stains; as am ingredient of one fluid ink eradicators, in electrodeposition of metals. It is used in textile dyeing; scouring of wool; buffer; food additive; detergent builder; water softener and dispersant. HUMAN EXPOSURE AND TOXICITY: Alkaline and irritating. Nausea, vomiting and diarrhea are probable after ingestion. Medical reports of acute exposures show mild to moderate dermal and ocular responses. ANIMAL STUDIES: Tetrasodium pyrophosphate when added to the diets of rats in high concentrations it caused kidney damage. This chemical caused teratogenic effects in chicken embryos. Acute studies show that direct contact causes severe irritation and corneal injury in the rabbit eye and that it may be irritating to skin. This chemical can be considered moderately toxic on ingestion, inducing metabolic acidosis, and hypocalcemia.

... Sodium pyrophosphate inhibits both the deposition of calcium salts and the formation of a calcifiable matrix in the aorta of rats treated with large doses of vitamin D.

3(?). 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ AND 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB). ... SOME ANIMAL DATA SUGGEST THAT PYROPHOSPHATE IS CONSIDERABLY (AND UNACCOUNTABLY) MORE TOXIC THAN IMPLIED BY TOXICITY RATING OF 3.

Pyrophosphate is hydrolyzed to the orthophosphate in the gut.

ARSONIC ACID HERBICIDES ARE NOT GROWTH REGULATORS IN SENSE OF PLANT HORMONES. THEY ... ACT THROUGH ENZYME SYSTEMS TO INHIBIT GROWTH. THEY KILL ... SLOWLY; FIRST SYMPTOMS ARE ... CHLOROSIS, CESSATION OF GROWTH, & GRADUAL YELLOWING, THEN BROWNING FOLLOWED BY DEHYDRATION & DEATH. /ORGANOARSENICAL HERBICIDES/

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, nose, throat; dermatitis Target Organs: Eyes, skin, respiratory system (NIOSH, 2016)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, promptly wash the contaminated skin with water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with water. If irritation persists after washing, get medical attention. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

ALKALINE AND IRRITATING. NAUSEA, VOMITING AND DIARRHEA ARE PROBABLE AFTER INGESTION.|Medical reports of acute exposures ... show mild to moderate dermal and ocular responses.

anhydrous sodium pyrophosphate

The substance can be absorbed into the body by inhalation of dust and by ingestion.|inhalation, ingestion, skin and/or eye contact

irritation eyes, skin, nose, throat; dermatitis

Cough. Sore throat.

Redness.

Redness. Pain.

Eyes, skin, respiratory system

65-69% USED IN INDUSTRIAL & INSTITUTIONAL DETERGENT BUILDERS & WATER TREATMENT APPLICATIONS; 13-15% USED IN CLAY PROCESSING; 3-5% IN FOOD & ALLIED PRODUCTS (OTHER THAN DAIRY); 1% IN DAIRY & ALLIED PRODUCTS; 13% IN MISC APPLICATIONS INCLUDING HOME LAUNDRY DETERGENTS, TEXTILES, ELASTOMERS, IN PAPER PROCESSING(1973)

TSPP IS USED IN VANILLA INSTANT PUDDING-MIX AT LEVELS OF 2.8 G/113.4 G OF MIX 2.8 G/127.6 G OF CHOCOLATE MIX. PATENT 2,607,692. /FROM TABLE/|CURAFOS USED IN.../MICROBIOLOGICAL INHIBITORY/ EXPERIMENTS CONTAINED 15% TSPP, 70% STPP, AND 15% SHMP; FIBRISOL CONTAINED 25% SAPP, 15% TSPP, 10% SHMP, AND 50% NACL. /PHOSPHATES/|TSPP IS USED IN VANILLA INSTANT PUDDING-MIX AT LEVELS OF 1.5 G/92.3 G OF MIX & 1.5 G/113.8 G OF CHOCOLATE MIX. PATENT 2,801,924. TSPP IS USED IN UNFLAVORED INSTANT PUDDING-MIX AT 2.2 G/100.0 G OF MIX. PATENT 3,231,391. /FROM TABLE/|GRADES: PURE CRYSTALS; DRIED; FUSED; CP; FCC.|MANUFACTURERS: ...COMMERCIAL MIXTURES OF PHOSPHATES NORMALLY USED IN CURING MEAT PRODUCTS /ARE/ (CURAFOS AND FIBRISOL, MANUFACTURED BY JA BENCKISER)...

All other basic organic chemical manufacturing|Diphosphoric acid, sodium salt (1:4): ACTIVE|.../COMPOUND IS/ NOW ALLOWED IN FROZEN DESSERTS AT LEVELS UP TO 0.2% /TO PREVENT CHURNING/.|...SEQUESTRANTS SUCH AS...PYROPHOSPHATE...WILL RETARD NITRIC OXIDE-HEMOGLOBIN FORMATION IN CURED MEATS BY CONTROLLING EFFECTS OF METAL IONS.|USED TO DECREASE AMT OF COOKED-OUT JUICES IN CURED HAMS AND PORK SHOULDER PICNICS, LOINS; CANNED HAMS &...CHOPPED HAM; BACON. /FROM TABLE/|USED TO PREVENT STAINING ON EXTERIOR OF VARIOUS CANNED GOODS DURING COOLING AND RETORT WATER TREATMENT. /FROM TABLE/|For more General Manufacturing Information (Complete) data for TETRASODIUM PYROPHOSPHATE (19 total), please visit the HSDB record page.

EPA Safer Chemical Functional Use Classes -> Oxidants and Oxidant Stabilizers|Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues|Food additives|Cosmetics -> Anticaking; Buffering; Chelating

Food Additives -> ACIDITY_REGULATOR; EMULSIFIER; SEQUESTRANT;