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3-(8,8-dipropyl-2-azaspiro[4.5]decan-2-yl)-N,N-diethylpropan-1-amine;dihydrochloride

3-(8,8-dipropyl-2-azaspiro[4.5]decan-2-yl)-N,N-diethylpropan-1-amine;dihydrochloride structure

CAS No:
130065-61-1
Formula:
C22H46Cl2N2
Chemical Name:
3-(8,8-dipropyl-2-azaspiro[4.5]decan-2-yl)-N,N-diethylpropan-1-amine;dihydrochloride
Synonyms:
antiprimod;atiprimod;azaspirane;N,N-diethyl-8,8-dipropyl-2-azaspiro(4.5)decane-2-propanamine dihydrochloride;SK and F 106615;SK and F 106615, dihydrochloride;SK and F-106615;SKF 106615;SKF-106615;Atiprimod dihydrochloride;130065-61-1;UNII-O12I24570R;SK&F 106615-A2;Atiprimod dihydrochloride [USAN];O12I24570R;SKF-106615-A2;2-Azaspiro(4.5)decane-2-propanamine, N,N-diethyl-8,8-dipropyl-, dihydrochloride;Atiprimod dihydrochloride (USAN);Atiprimod HCl;Atiprimod hydrochloride;SKF 1006615-A2;SCHEMBL5116678;CHEMBL3215883;DTXSID20156331;AKOS024458234;SK&F-106615-A2;SK&F-106615-I2;2-(3-(Diethylamino)propyl)-8,8-dipropyl-2-azaspiro(4.5)decane dihydrochloride;D03003;Q27285187;2-Azaspiro(4.5)decane-2-propanamine N,N-diethyl-8,8-dipropyl-, dihydrochloride;N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride;N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanaminedihydrochloride

Description

Atiprimod Dihydrochloride is the dihydrochloride salt form of atiprimod, an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and anti-angiogenic activities. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and AKT, blocking the signaling pathways of interleukin-6, vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1. This results in the inhibition of cell proliferation, induction of cell cycle arrest, and apoptosis.

3-(8,8-dipropyl-2-azaspiro[4.5]decan-2-yl)-N,N-diethylpropan-1-amine;dihydrochloride Basic Attributes

Molecular Weight：

409.5 g/mol

Exact Mass：

408.3038049 g/mol

UNII：

O12I24570R

DSSTox ID：

DTXSID20156331

NCI Thesaurus Code：

C76969

Characteristics

PSA：

6.5 Å²

Drug Information

MeSH Entry Terms：

antiprimod

Computed Properties

Molecular Weight:409.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:10
Exact Mass:408.3038049
Monoisotopic Mass:408.3038049
Topological Polar Surface Area:6.5
Heavy Atom Count:26
Complexity:332
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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Guide of 3-(8,8-dipropyl-2-azaspiro[4.5]decan-2-yl)-N,N-diethylpropan-1-amine;dihydrochloride

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties

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