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N-Methylparoxetine

N-Methylparoxetine structure

CAS No:
110429-36-2
Formula:
C20H22FNO3
Chemical Name:
N-Methylparoxetine
Synonyms:
N-METHYLPAROXETINE;(3S,4R)-3-(3,4-Methylene-dioxyphenoxy-methyl)-4-(4'-fluorophenyl)-N-methylpiperidine;3-S TRANS (-3-[1,3 BENZODIOXOL-5-YLOXY) METHYL-]4'(4-FLUORO PHENYL)N-METHYL PIPERIDINE;METHYL PAROXETINE;(3s,4r)-1-Methyl-3-[(3,4-(Methylenedioxy)Phenoxy)Methyl]-4-(4-Fluoropheny)-Piperidine;Trans-(-)-4-(4'-Fluoro Phenyl)-3-[[3,4-(Methylenedioxy)-Phenoxy]-Methyl]-N-Methylpiperidine;Methylparodextine;(-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)-1-methylpiperidine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

N-methylparoxetine is a member of the class of benzodioxoles that is paroxetine in which the piperidine hydrogen is substituted by a methyl group. It is a drug impurity of the antidepressant, paroxetine. It has a role as an apoptosis inducer, a serotonin uptake inhibitor and an impurity. It is a member of benzodioxoles, an aromatic ether, a member of piperidines, a tertiary amino compound and a member of monofluorobenzenes. It derives from a paroxetine.

Off-White Solid

N-Methylparoxetine Basic Attributes

Molecular Weight：

343.39

Exact Mass：

343.39

BRN：

7468178

EC Number：

1312995-182-4

UNII：

3X658583PO

DSSTox ID：

DTXSID20149243

Color/Form：

Off-White to Pale Yellow

HScode：

2933.39.9200

Characteristics

Density：

1.198±0.06 g/cm3(Predicted)

Melting Point：

109.0 to 113.0 °C

Boiling Point：

443.7±45.0 °C(Predicted)

PKA：

8.48±0.20(Predicted)

Critical Temperature & Pressure：

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Safety Information

wgk germany：

WGK 3

hazard class code：

T,N

safety instructions：

45-60-61

Hazard Statements：

25-50/53

RIDADR：

UN 2811 6.1 / PGIII

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, and P501|Aggregated GHS information provided by 3 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301 (95%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501|Aggregated GHS information provided by 41 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

N-Methylparoxetine Use and Manufacturing

A drug impurity of Paroxetin, a selective serotonin reuptake inhibitor. Paroxetine USP Related Compound F.

Recommended Suppliers of N-Methylparoxetine

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CAS No.: 110429-36-2

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N-Methylparoxetine 99.0%Min Off-White to Pale Yellow solid RC00956

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N-Methylparoxetine

CAS No.: 110429-36-2

Grade: Analytical Reagent

Content: 99%

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