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α-Lipoic Acid

α-Lipoic Acid structure

CAS No:
1077-28-7
Formula:
C8H14O2S2
Chemical Name:
α-Lipoic Acid
Synonyms:
5 MG PNPP SUBSTRATE TABLETS REAGENT GR;(1)-ALPHA-LIPOIC ACID;DL-α-Lipoic acidUSP, 99.0-101.0% (Assay);5-(1,2)Dithiolan-3-yl-pentanoic acid for synthesis;TIMTEC-BB SBB003484;THIOOCTIC ACID;dl-1,2-Dithiolane3-valericacid;DL-6-Thioctic acid
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

Description

DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant. DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.

Light-Yellow Solid

ChEBI: Lipoic acid is a heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position. It has a role as a fundamental metabolite and a geroprotector. It is a member of dithiolanes, a heterocyclic fatty acid and a thia fatty acid. It is functionally related to an octanoic acid. It is a conjugate acid of a lipoate.

Oxidized form. Has antioxidant properties. Growth factor for many bacteria and protozoa.

Animal products like red meat and organ meats are great sources of α-Lipoic Acid, but plant foods like broccoli, tomatoes, spinach, and Brussels sprouts also contain it.

α-Lipoic Acid Basic Attributes

Molecular Weight：

206.33

BRN：

81853

EC Number：

214-071-2

Color/Form：

Yellow

HScode：

29349990

Characteristics

Density：

1.2888 (rough estimate)

Melting Point：

60-62 °C

Boiling Point：

160-165 °C(lit.)

Refractive Index：

1.5200 (estimate)

Water Solubility：

0.9 g/L (20 ºC)

Flammability characteristics：

Not classified

PKA：

4.75±0.10(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

hazard class code：

safety instructions：

37/39-26-24/25-36-36/37/39

RTECS Number：

JP1192000

Storage features：

Store at +4°C

Hazard Statements：

22-20/21/22

α-Lipoic Acid Use and Manufacturing

Lipoic acid [CAS: 1077-28-7] (6,8-dimercaptooctanoic acid), a lipophilic endogenous disulfide that can be reduced to the dithiol dihydrolipoic acid, protects against free-radical-mediated injury both in vivo and in vitro.

A fat-metabolism stimulator

thioctic acid is also known as alpha lipoic acid. It is an anti-oxidant.

(±)-α-Lipoic acid has been used inin vitrolipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay. It has also been used to investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period.

Material

Acetic acid

Drug Function and Efficacy

Thioctic acid, also known as alpha-lipoic acid, is an antioxidant that helps neutralize free radicals in the body. It may support cellular health and has potential benefits in managing oxidative stress-related conditions.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Manufacturer	CP Skin Health Group, Inc

Registered Holders

立山化成株式会社

Japan
Active

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