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1,3-Butanediol

1,3-Butanediol structure

CAS No:
107-88-0
Formula:
C4H10O2
Chemical Name:
1,3-Butanediol
Synonyms:
(±)-butane-1,3-diol;1,3-Butandiol;Methyltrimethylene;Methyltrimethylene glycol;methyltrimethyleneglycol;1-METHYLTRIMETHYLENE GLYCOL;1,3-DIHYDROXYBUTANE;1,3-BUTANEDIOL
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

1,3-Butanediol is an organic chemical which belongs to the family of secondary alcohols. At present, 1,3-butanediol is used mainly in surfactants, inks, solvents for natural and synthetic flavoring agents and serves as a co-monomer in manufacturing certain polyurethane and polyester resins. It can also serve as a humectant to prevent loss of moisture in cosmetics, particularly in hair sprays and setting lotions. Besides, 1,3-Butanediol is pharmaceutically involved in the production of colchicine derivatives as a anticancer agent and in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as a hypoglycaemic agent, which is effective for the treatment of diabetes.

colourless liquid

Butylene glycol occurs as a clear, colorless, viscous liquid with a sweet flavor and bitter aftertaste.

1,3-Butanediol is a colorless oily liquid. Sp.Gr. 1.00. B.P. 207℃. Miscible with water, soluble in alcohol and many perfume and flavor materials, but poorly soluble in hydrocarbons (terpenes, etc.). 1,3-Butylene glycol has a sweet flavor with bitter aftertaste and is odorless when pure.

ChEBI: A butanediol compound having two hydroxy groups in the 1- and 3-positions.

1,3-Butanediol Basic Attributes

Molecular Weight：

90.12

BRN：

1731276

EC Number：

203-529-7

TSCA：

TSCA listed

Color/Form：

Clear colorless to yellow, may discolor to brown on storage

HScode：

29053920

Characteristics

Density：

1.005 g/mL at 25 °C(lit.)

Melting Point：

-54 °C

Boiling Point：

203-204 °C(lit.)

Refractive Index：

n20/D1.44(lit.)

Water Solubility：

SOLUBLE

Vapor Pressure：

0.06 mm Hg ( 20 °C)

Vapor Density：

3.1 (20 °C, vs air)

Toxicity：

LD50 orally in Rabbit: 18610 mg/kg LD50 dermal Rabbit > 20000 mg/kg

Flammability characteristics：

Not classified

Odor：

odorless

PH：

6.1 (500g/l, H2O, 20℃)

PKA：

14.83±0.20(Predicted)

Henrys Law Constant：

7.0×103mol/(m3Pa) at 25℃, Burkholder et al. (2019)

Autoignition Temperature：

741 °F

Critical Temperature & Pressure：

Store below +30°C.

Safety Information

wgk germany：

safety instructions：

24/25

RTECS Number：

EK0440000

Storage features：

Butylene glycol is hygroscopic and should be stored in a well-closed container in a cool, dry, well-ventilated place. When heated to decomposition, butylene glycol emits acrid smoke and irritating fumes.

Hazardous Reactivities：

Butylene glycol is incompatible with oxidizing reagents.

Exposure Prevention：

This dihydric alcohol is used for its humectant and preservative potentiator properties in cosmetics, topical medicaments and polyurethane, polyester, cellophane, and cigarettes. It has similar properties, but is less irritant than propylene glycol. Contact allergies seem to be rare.

1,3-Butanediol Use and Manufacturing

Uses

(^+)-1,3-Butanediol acts as a co-monomer in the production of polyurethane and polyester resins. It is used as a humectant (to prevent loss of moisture) in cosmetics, especially in hair sprays and setting lotions. It is used in surfactants, inks, solvents for natural and synthetic flavorings. It is involved in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycemic agents, which is used in the treatment of diabetes.

1,3-Butanediol is used in the synthesis of colchicine derivatives as anticancer agents. Also used in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycem ic agents in the treatment of diabetes.

Its most extensive use is as an intermediate in the manufacture of polyester plasticisers and other chemical products. It finds some use as a solvent and humectant, a useful chemical intermediate. It has extensive application in the manufacture of structural materials for boats, custom mouldings, and sheets and boards for construction applications. 1,3-Butanediol imparts resistance to weathering plus flexibility and impact resistance. It is also used in the manufacture of saturated polyesters for polyurethane coatings, where the glycol imparts greater flexibility to the polyester molecule. 1,3-Butanediol is currently used in many personal care products.

Production

Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel.

Material

Propylene

Butanal

Drug Function and Efficacy

Humectant and solvent, improves moisture retention and enhances penetration of active ingredients

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Wuhan Pnq Int Trade Co., Ltd Contact Supplier

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Unit Price: $100 /KG EXW

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Suzhou Cornigs Biological Products Co., Ltd. Contact Supplier

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Unit Price: $1000 /MT FOB

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