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Tephrosin

Tephrosin structure

CAS No:
76-80-2
Formula:
C23H22O7
Chemical Name:
Tephrosin
Synonyms:
3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one,13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-,(7aR,13aR)-;Tephrosin;3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one,13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-,(7aR-cis)-;(7aR,13aR)-13,13a-Dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one;Deguelinol I;Hydroxydeguelin;(-)-Tephrosin;16277-83-1
Categories:
Biochemical Engineering > Chinese Herbs

Description

Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors[1].

Tephrosin is a member of the class of rotenones that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted with geminal methyl groups at position 3, hydroxy group at position 7a and methoxy groups at positions 9 and 10 (the 7aR,13aR stereoisomer). It is isolated from the leaves and twigs of Antheroporum pierrei and exhibits antineoplastic and pesticidal activities. It has a role as a pesticide, an antineoplastic agent and a metabolite. It is an organic heteropentacyclic compound, an aromatic ether, a cyclic ketone and a member of rotenones.

Tephrosin Basic Attributes

Molecular Weight：

410.41658

Exact Mass：

410.42

UNII：

9C081V83CC

Characteristics

PSA：

83.45000

XLogP3：

4.48

Density：

1.3±0.1 g/cm3

Melting Point：

198 °C

Boiling Point：

623.4±55.0 °C at 760 mmHg

Flash Point：

219.3±25.0 °C

Refractive Index：

1.614

Storage Conditions：

-20°C

Safety Information

Transport codes：

UN 3077 9 / PGIII

wgk germany：

hazard class code：

safety instructions：

Marks：

Precautionary statement(s)：

P273-P501

Hazard Statements：

H410

Drug Information

MeSH Entry Terms：

tephrosin

Tephrosin Use and Manufacturing

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Rotenoid flavonoids [PK1206]

Computed Properties

Molecular Weight:410.4
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:410.13655304
Monoisotopic Mass:410.13655304
Topological Polar Surface Area:83.4
Heavy Atom Count:30
Complexity:720
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Tephrosin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

Tephrosin

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