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Naphazoline nitrate

Naphazoline nitrate structure

CAS No:
5144-52-5
Formula:
C14H14N2.HNO3
Chemical Name:
Naphazoline nitrate
Synonyms:
1H-Imidazole,4,5-dihydro-2-(1-naphthalenylmethyl)-,nitrate (1:1);2-Imidazoline,2-(1-naphthylmethyl)-,mononitrate;1H-Imidazole,4,5-dihydro-2-(1-naphthalenylmethyl)-,mononitrate;Naphtyzin;Naphazoline nitrate;Naphthylmethyl-2-imidazoline nitrate;Naphthisin;Naftizin;Rinazin;Naphthizin;Privine nitrate;Privine;Privine (British);Sanorin;Privina;Privin;2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole nitrate
Categories:
Analytical Chemistry > Standard

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Description

White or almost white, crystalline powder.

Naphazoline nitrate is a member of naphthalenes.|An adrenergic vasoconstrictor agent used as a decongestant.

Naphazoline nitrate Basic Attributes

Molecular Weight：

273.29

Exact Mass：

273.111328

BRN：

3779329

EC Number：

225-915-4

UNII：

SC99GR1T5S

DSSTox ID：

DTXSID90143430

HScode：

2934999090

Characteristics

PSA：

90.4

XLogP3：

2.32390

Appearance：

white solid

Melting Point：

167-168 °C @ Solvent: Isopropanol

Boiling Point：

440.5ºC at 760mmHg

Flash Point：

220.2ºC

Water Solubility：

In water, 4.0X10+5 mg/L at 25 deg C

Storage Conditions：

Naphazoline hydrochloride ophthalmic solutions should be protected from light and should be stored in tight, light-resistant containers. The drug is degraded in the presence of aluminum and, therefore, should not be stored in aluminum containers. Fixed combinations containing naphazoline hydrochloride and antazoline phosphate should be stored at temperatures less than 25 deg C.

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

safety instructions：

22-36/37-60-36

RTECS Number：

NJ4376000

Marks：

Stability/Shelf Life：

NAPHAZOLINE HYDROCHLORIDE WAS STABLE FOR 2 MO @ 5 & 15 DEG C.

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 43 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)|Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)

MeSH Entry Terms：

Afazol Grin

Naphazoline nitrate Use and Manufacturing

antihistamine

Computed Properties

Molecular Weight:273.29
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:273.11134135
Monoisotopic Mass:273.11134135
Topological Polar Surface Area:90.4
Heavy Atom Count:20
Complexity:297
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Downstream Products

Neomycin sulfate

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CAS No.: 5144-52-5

Grade: Pharmaceutical Grade

Content: 99%

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