 Home > Encyclopedia > Aflatoxin M1

Aflatoxin M1

Aflatoxin M1 structure

CAS No:
6795-23-9
Formula:
C17H12O7
Chemical Name:
Aflatoxin M1
Synonyms:
Cyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-,(6aR,9aR)-;Cyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-,(6aR-cis)-;1-Cyclopentene-1-carboxylic acid,2-(3a,8a-dihydro-3a,4-dihydroxy-6-methoxyfuro[2,3-b]benzofuran-5-yl)-5-oxo-,δ-lactone;(6aR,9aR)-2,3,6a,9a-Tetrahydro-9a-hydroxy-4-methoxycyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione;AFM1;Aflatoxin M1
Categories:
Analytical Chemistry > Standard

Description

Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2[1].

Solid

Aflatoxin M1 is a member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at position 9a is replaced by a hydroxy group. It has a role as a mammalian metabolite, a human xenobiotic metabolite and an Aspergillus metabolite. It is an aflatoxin, an aromatic ether, a tertiary alcohol and an aromatic ketone. It derives from an aflatoxin B1.|A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates and rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).

Aflatoxin M1 Basic Attributes

Molecular Weight：

328.27

Exact Mass：

328.27

EC Number：

229-865-4

UNII：

I3020O28I3

HScode：

29322090

Characteristics

PSA：

95.20000

XLogP3：

-0.35

Appearance：

Solid

Density：

1.7±0.1 g/cm3

Melting Point：

299 °C

Boiling Point：

644.3±55.0 °C at 760 mmHg

Flash Point：

11 °C

Refractive Index：

1.718

Storage Conditions：

2-8°C

Toxicity：

Oral-rat LDL0：1.50 mg/kg

Flammability characteristics：

Flammable; burning releases irritating fumes

Specific rotation：

D -280° (c = 0.1 in DMF)

Collision Cross Section：

166 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|179.5 Å² [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine]|177.8 Å² [M+K]+ [CCS Type: TW, Method: calibrated with polyalanine]|173.78 Å² [M-H]-

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 3462 6.1/PG 1

wgk germany：

hazard class code：

26/27/28-40-39/23/24/25-23/25-23/24/25-11-36-20/21/22-45

safety instructions：

53-22-36/37/39-45-24-16-7-36-26-36/37-28

RTECS Number：

GY1880000

Marks：

T+,T,F,Xn

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Precautionary statement(s)：

P201-P260-P264-P280-P284-P301 + P310

Hazard Statements：

H300-H310-H330-H350

GHS Classification：

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P262, P264, P270, P271, P280, P281, P284, P301+P310, P302+P350, P304+P340, P308+P313, P310, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

most toxic

Drug Information

MeSH：

Substances which, when ingested, inhaled, or absorbed, or when applied to, injected into, or developed within the body in relatively small amounts may, by their chemical action, cause damage to structure or disturbance of function. (From Dorland, 27th ed) (See all compounds classified as Poisons.)

Metabolism/Metabolites：

Aflatoxin M1 is a known human metabolite of aflatoxin b1.

MeSH Entry Terms：

4 Hydroxyaflatoxin B1

Aflatoxin M1 Use and Manufacturing

Uses

An Aspergillus flavus metabolite. Aflatoxin M1 in milk as a secondary metabolite of the Aflatoxin B1 formed in moldy forages.It is cancerogenic, hepatotoxic, and immunosuppressive in animals and man.

Food Additive Classes：

Food Contaminant -> MYCOTOXIN;

Computed Properties

Molecular Weight:328.27
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:328.05830272
Monoisotopic Mass:328.05830272
Topological Polar Surface Area:91.3
Heavy Atom Count:24
Complexity:695
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Aflatoxin M1

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Aflatoxin M1

CAS No.: 6795-23-9

Content: 99.00%

Inquiry
Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

AFLATOXIN M1/

CAS No.: 6795-23-9

Grade: Chemical Grade

Content: 99%

Inquiry