3-Nitro-o-xylene

151.16

151.16

2045105

201-474-3

49GNX4CY5W

5402

1665

DTXSID7025132

Pale yellow oil

29042000

45.8

2.83

1,2-dimethyl-3-nitrobenzene is a yellow liquid. (NTP, 1992)

1.1402 g/cm³ @ Temp: 20 °C

15 °C

240 °C

226 °F

1.547

H2O: 117 mg/L (25 ºC)

Store below +30°C.

0.0172 mm Hg at 25 deg C /extrapolated/

5.22 (NTP, 1992) (Relative to Air)

Henry's Law constant = 5.11X10-5 atm-cu m/mole at 25 °C (est)

Hydroxyl radical reaction rate constant = 1.05X10-12 cu cm/molecule-sec at 25 °C (est)

Insoluble in water.

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

1,2-DIMETHYL-3-NITROBENZENE is incompatible with strong oxidizers and strong bases (NTP, 1992).

II

6.1

UN 3082 9/PG 3

2

51/53-36/37/38-23/24/25-20/21

61-45-36/37/39-26-13-36/37-23-9

N,T

Stable under normal temperatures and pressures.

P273, P391, P501

H411

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

This chemical is combustible. (NTP, 1992)

|H411 (94.85%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]|P273, P391, and P501|Aggregated GHS information provided by 135 companies from 5 notifications to the ECHA C&L Inventory.

Fires involving this material can be controlled with a dry chemical, carbon dioxide, or Halon extinguisher. A water spray may also be used. (NTP, 1992)

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material under ambient temperatures. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

LD50 Rat oral (female) 2110 mg/kg body weight|LD50 Rat (male) oral 2380 mg/kg body weight

1,2-Dimethyl-3-nitrobenzene's production and use as a starting material for the production of agrochemicals and as an intermediate for the production of dyes and colorants(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 606(SRC), determined from a structure estimation method(2), indicates that 1,2-dimethyl-3-nitrobenzene is expected to have low mobility in soil(SRC). Volatilization of 1,2-dimethyl-3-nitrobenzene from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.11X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(2). 1,2-Dimethyl-3-nitrobenzene is not expected to volatilize from dry soil surfaces(SRC) based upon an extrapolated vapor pressure of 0.0172 mm Hg at 25 °C(3). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(4) indicating that biodegradation is not an important environmental fate process in soil. However, studies of analogous 2- and 4-methylnitrobenzene have shown that biodegradation of these compounds in acclimated media can be relatively fast with 98-100% degradation within a few days to a few weeks(5-7).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 606(SRC), determined from a structure estimation method(2), indicates that 1,2-dimethyl-3-nitrobenzene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 5.11X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 25 hours and 11 days, respectively(SRC). According to a classification scheme(4), a BCF of 724(5) suggests the potential for bioconcentration in aquatic organisms is high. Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(6) indicating that biodegradation is not an important environmental fate process in water. However, studies of analogous 2- and 4-methylnitrobenzene have shown that biodegradation of these compounds in acclimated media can be relatively fast with 98-100% degradation within a few days to a few weeks(7-9).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2-dimethyl-3-nitrobenzene, which has an extrapolated vapor pressure of 0.0172 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,2-dimethyl-3-nitrobenzene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 15 days(SRC), calculated from its rate constant of 1.05X10-12 cu cm/molecule-sec at 25 °C(SRC), determined using a structure estimation method(3). By analogy to methylnitrobenzenes(4), 1,2-dimethyl-3-nitrobenzene is expected to be susceptible to direct photolysis in sunlight(SRC).

The rate constant for the vapor-phase reaction of 1,2-dimethyl-3-nitrobenzene with photochemically-produced hydroxyl radicals has been estimated as 1.05X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 15 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1,2-Dimethyl-3-nitrobenzene is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2). Methylnitrobenzenes have measurable quantum yields at 313 nm and therfore are susceptible to direct photolysis in sunlight(3). By analogy, 1,2-dimethyl-3-nitrobenzene is expected to be susceptible to direct photolysis(SRC).

A log BCF of 2.86 (BCF = 724) for 1,2-dimethyl-3-nitrobenzene was measured in guppies (Poecilla reticulata) during a 3-day static-flow test, measurement based on a fat-weight basis(1). According to a classification scheme(2), this log BCF suggests bioconcentration in aquatic organisms is high(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1,2-dimethyl-3-nitrobenzene can be estimated to be 606(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1,2-dimethyl-3-nitrobenzene is expected to have low mobility in soil.

The Henry's Law constant for 1,2-dimethyl-3-nitrobenzene is estimated as 5.11X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 1,2-dimethyl-3-nitrobenzene is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 25 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 11 days(SRC). 1,2-Dimethyl-3-nitrobenzene's Henry's Law constant indicates that some volatilization from moist soil surfaces may occur(SRC). 1,2-Dimethyl-3-nitrobenzene is not expected to volatilize from dry soil surfaces(SRC) based upon an extrapolated vapor pressure of 0.0172 mm Hg at 25 °C(3).

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of 1,2-dimethyl-3-nitrobenzene is 1 to 99; the data may be greatly underestimated(1).|Occupational exposure to 1,2-dimethyl-3-nitrobenzene may occur through dermal contact with this compound at workplaces where 1,2-dimethyl-3-nitrobenzene is produced or used. (SRC)

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, mucous membranes and upper respiratory tract and cyanosis. Similar chemicals cause methemoglobinemia. ACUTE/CHRONIC HAZARDS: This compound may be fatal if inhaled, swallowed or absorbed through the skin. Vapor or mist is irritating to the eyes, skin, mucous membranes and upper respiratory tract. When heated to decomposition this compound may emit toxic fumes of carbon monoxide, carbon dioxide and oxides of nitrogen. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

Pesticide, fertilizer, and other agricultural chemical manufacturing|Benzene, 1,2-dimethyl-3-nitro-: ACTIVE