 Home > Encyclopedia > Concanamycin B

Concanamycin B

Concanamycin B structure

CAS No:
81552-33-2
Formula:
C45H73NO14
Chemical Name:
Concanamycin B
Synonyms:
Oxacyclooctadeca-3,5,13,15-tetraen-2-one,18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-8,10-dihydroxy-3,17-dimethoxy-5,7,9,11,13-pentamethyl-,(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-;Concanamycin A,8-deethyl-8-methyl-;Oxacyclooctadecane,concanamycin A deriv.;(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-8,10-dihydroxy-3,17-dimethoxy-5,7,9,11,13-pentamethyloxacyclooctadeca-3,5,13,15-tetraen-2-one;Concanamycin B;MCH 210
Categories:
Organic Chemistry > Lactones

Request for Quotation

Concanamycin B Basic Attributes

Molecular Weight：

852.059

Exact Mass：

852.06

NSC Number：

670977

Characteristics

PSA：

225.92000

XLogP3：

3.34

Density：

1.2±0.1 g/cm3

Boiling Point：

960.2±65.0 °C at 760 mmHg

Flash Point：

534.5±34.3 °C

Refractive Index：

1.556

Drug Information

MeSH Entry Terms：

concanamycin B

Concanamycin B Use and Manufacturing

Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A. Like other concanamycins and bafilomycins, concanamycin B inhibits vacuolar H(+)-ATPase. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro.

Computed Properties

Molecular Weight:852.1
XLogP3:5.6
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:11
Exact Mass:851.50310600
Monoisotopic Mass:851.50310600
Topological Polar Surface Area:226
Heavy Atom Count:60
Complexity:1560
Defined Atom Stereocenter Count:5
Undefined Atom Stereocenter Count:13
Defined Bond Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes