3,3'-Dithiobis(sulfosuccinimidylpropionate)
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3,3'-Dithiobis(sulfosuccinimidylpropionate)
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CAS No:
81069-02-5
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Formula:
C14H14N2Na2O14S4
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Chemical Name:
3,3'-Dithiobis(sulfosuccinimidylpropionate)
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Synonyms:
DTSSP Crosslinker;3,3'-Dithiobis(sulfosuccinimidylpropionate);DTSSP 3,3'-Dithiobis(sulfosucciniMidylpropionate);3,3Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester;3,3’-Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester 90%;3,3`-Dithiobis(sulfosucciniMidylpropionate)(DTSSP(Sulfo-DSP))
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CAS No:
Description
DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
3,3'-Dithiobis(sulfosuccinimidylpropionate) Basic Attributes
564.54200
563.94800
DTXSID30276271
29309090
Safety Information
26-36
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other. (See all compounds classified as Cross-Linking Reagents.)
3,3'-dithiobis(sulfosuccinimidyl propionate)
3,3'-Dithiobis(sulfosuccinimidylpropionate) Use and Manufacturing
sulfhydryl reactive cleavable heterobifunctional cross-linking reagent, pyridine-2-thione release can be monitored at 343 nm after reactions with sulfhydryl groups It is a water-soluble, thiol cleavable, homobifunctional and amine-reactive crosslinking agent.
Computed Properties
Molecular Weight:564.6
XLogP3:-2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:13
Exact Mass:563.94843788
Monoisotopic Mass:563.94843788
Topological Polar Surface Area:304
Heavy Atom Count:34
Complexity:1020
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
3,3'-Dithiobis(sulfosuccinimidylpropionate)
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