2-(2-CHLOROETHOXY)-BENZENESULFONAMIDE

The preparation method is to add 4-chlorophenol, dichloroethane, catalyst and sodium hydroxide solution into the reaction kettle, heat and stir, and react for several hours to obtain 1-(4-chlorophenoxy)-2-chloroethyl The compound is sulfonated with chlorosulfonic acid dropwise at 0～5℃ in dichloroethane, the reaction temperature is 25～30℃, and the temperature is kept for 3 h to obtain 2-(β-chloroethoxy)-5-chlorobenzene Sulfonyl chloride. The compound is slowly added with 30% sodium hydroxide solution at 35～40℃, and the obtained 5-chloro-2-(β-chloroethoxy)benzenesulfonate sodium is at 40～60℃, using palladium/carbon as catalyst, Catalytic hydrogenation is carried out at a pressure of 100 kPa to remove the chlorine atom from the benzene ring, and 30% sodium hydroxide solution is continuously added to maintain the pH value between 9.5 and 11.5 to obtain sodium 2-(β-chloroethoxy)benzene sulfonate , Dilute with chlorobenzene, add catalyst DMF, and continuously pass in phosgene to maintain at 90℃ for 2～3 h to obtain 2-(β-chloroethoxy)benzenesulfonyl chloride, add moisture layer, and separate organic layer React with 30% ammonia solution to generate 2-(β-chloroethoxy)benzenesulfonamide chlorobenzene solution, which is heated to remove chlorobenzene to obtain finished product. It is also possible to use divinyl carbonate instead of 1, 2-dichloroethane for the reaction. In addition, 2-(β-chloroethoxy)-aniline can be used as the raw material to generate 2-(β-chloroethoxy)benzenesulfonyl chloride by diazotizing, adding sodium bisulfite and the catalyst copper sulfate and hydrochloric acid. , And then react with ammonia to produce finished products.

Intermediate for synthesis of sulfonylurea pesticides

Molecular Weight:235.69
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:235.0069920
Monoisotopic Mass:235.0069920
Topological Polar Surface Area:77.8
Heavy Atom Count:14
Complexity:262
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes