7-METHOXY-2-NAPHTHOL

White to brown solid

General procedure: A mixture of 2-hydroxy-1-nitronaphthalene (500 mg, 2.64 mmol), dimethyl sulfate (0.5 ml, 5.3 mmol), and K2CO3 (73.1 mg, 5.3 mmol) inacetonitrile (10 ml) was refluxed for 1hrs. The solvent was evaporated and the residue waspoured into water and extracted with ethyl acetate. The organic layer was washed with waterand brine and dried over anhydrous MgSO4 and concentrated in vacuo. The residue waspurified by column chromatography on silica gel with nhexane/ethyl acetate (15:1) as theeluent to obtain the productStep A: Sodium hydroxide (20 ml, 1M) and dimethyl sulfate (15.0 ml, 158 mmol) were added dropwise to a solution of 2, 7-dihydroxynaphthalene (6.6 g, 40 mmol) in dichloromethane (100 ml) and water (60 ml). Additional sodium hydroxide (20 ml, 1M) and dimethyl sulfate (15.0 ml, 158 mmol) were added and the resulting mixture was stirred at room temperature for 2 hours. The two phases were separated and the aqueous layer was extracted with dichloromethane twice. The combined organic extracts were washed with 1 M HCl, dried over magnesium sulfate and concentrated under vacuum. The crude material was purified by column chromatography (5:1 heptane/ethyl acetate) to give 2-hydroxy-7-methoxynaphthalene (2.1 g, 30percent, 100percent AUC HPLC): [0709] To a mixture of naphthalene-2, 7-diol (25 g, 156.08 mmol) and K

Molecular Weight:174.20
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:174.068079557
Monoisotopic Mass:174.068079557
Topological Polar Surface Area:29.5
Heavy Atom Count:13
Complexity:170
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes