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Dicyclomine hydrochloride

Dicyclomine hydrochloride structure

CAS No:
67-92-5
Formula:
C19H35NO2.ClH
Chemical Name:
Dicyclomine hydrochloride
Synonyms:
[1,1′-Bicyclohexyl]-1-carboxylic acid,2-(diethylamino)ethyl ester,hydrochloride (1:1);[Bicyclohexyl]-1-carboxylic acid,2-(diethylamino)ethyl ester hydrochloride;[1,1′-Bicyclohexyl]-1-carboxylic acid,2-(diethylamino)ethyl ester,hydrochloride;Atumin;Bentyl hydrochloride;Dicyclomine hydrochloride;β-Diethylaminoethyl 1-cyclohexylcyclohexanecarboxylate hydrochloride;Diocyl hydrochloride;Merbentyl;Wyovin hydrochloride;Dicycloverin hydrochloride;Di-Syntramine;Mamiesan;Procyclomin;Benacol;Bentomine;Dyspas;Dicycloverine hydrochloride;2-(Diethylamino)ethyl [1,1′-bi(cyclohexane)]-1-carboxylate hydrochloride;79988-11-7
Categories:
Analytical Chemistry > Standard

Description

White Crystalline Powder

Dicyclomine Hydrochloride is the hydrochloride salt form of dicyclomine, a synthetic analog of acetylcholine with antimuscarinic activity. Dicyclomine hydrochloride antagonizes muscarinic receptors on smooth muscle in the gastrointestinal (GI) tract, thereby preventing the actions of acetylcholine and reducing GI smooth muscle spasms.|A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.

Dicyclomine hydrochloride Basic Attributes

Molecular Weight：

345.95

Exact Mass：

345.24300

EC Number：

200-671-1

UNII：

CQ903KQA31

NSC Number：

756727

DSSTox ID：

DTXSID0058778

NCI Thesaurus Code：

C28987

HScode：

2922199695

Characteristics

PSA：

29.54000

XLogP3：

5.20420

Appearance：

off-white powder

Melting Point：

165 °C

Boiling Point：

399.8ºC at 760 mmHg

Flash Point：

116.5ºC

Water Solubility：

H2O: 50 mg/mL

Storage Conditions：

-20°C Freezer

Toxicity：

Oral-rat LD50: 625 mg/kg; Oral-Mouse LD50: 625 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes; patient side effects of medication; stiffness, difficulty breathing, pale

Collision Cross Section：

179.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

26-36

RTECS Number：

DT7350000

Marks：

Storage features：

Ventilated, low temperature and dry

Precautionary statement(s)：

P301 + P312 + P330-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 94 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

MeSH Entry Terms：

Bentyl

Dicyclomine hydrochloride Use and Manufacturing

Uses

Used as a gastrointestinal antispasmodic antacid

Manufacturing Info：

[1,1'-Bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester, hydrochloride (1:1): INACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:345.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:345.2434571
Monoisotopic Mass:345.2434571
Topological Polar Surface Area:29.5
Heavy Atom Count:23
Complexity:326
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Latest News on Dicyclomine hydrochloride

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Guide of Dicyclomine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Latest News
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