Amodiaquine hydrochloride
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Amodiaquine hydrochloride
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CAS No:
69-44-3
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Formula:
C20H22ClN3O.2ClH
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Chemical Name:
Amodiaquine hydrochloride
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Synonyms:
Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-,hydrochloride (1:2);o-Cresol,4-[(7-chloro-4-quinolyl)amino]-α-(diethylamino)-,dihydrochloride;Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-,dihydrochloride;Amodiaquine dihydrochloride;Camoquin hydrochloride;7-Chloro-4-(3′-diethylaminomethyl-4′-hydroxyanilino)quinoline dihydrochloride;4-(7-Chloro-4-quinolylamino)-α-(diethylamino)-o-cresol dihydrochloride;Amodiaquine hydrochloride;Amodiaquin dihydrochloride;Basoquine
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CAS No:
Description
Yellow crystalline solid; odorless; bitter. Soluble in water; sparingly soluble in alcohol; very slightly soluble in benzene, chloroform, and ether.
A 4-aminoquinoline compound with anti-inflammatory properties.
Safety Information
3
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 18 companies from 1 notifications to the ECHA C&L Inventory.
Drug Information
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)
Amodiachin
Amodiaquine hydrochloride Use and Manufacturing
In the three-neck bottle 16.0g diethylamine, 40.0g deionized water, 30.0g acetaminophen and 6.6g paraformaldehyde, heating to 80 °C, thermal insulation reaction 30 minutes, cooling to 40 °C the following, by adding 48g37percent after the hydrochloric acid, is heated to 104 °C, thermal insulation reaction 2 hours, after the reaction, lowering the temperature to 38 °C -42 °C, dropwise NaOH solution, adjusted to pH 3.0, adding 4, 7-chloroquinoline 36.2g, heating to 100 °C, thermal insulation reaction 1 hour, after the reaction, cooling to 3 °C -7 °C, stirring crystallization 2 hours to 3 hours, filtered, to control the temperature to 60 °C -70 °C, vacuum ≥ - 0.080 MPa, drying 8 hours to obtain Amodiaquine hydrochloride 85.69g, yield 92.89percent, purity of 99.96percent.
Medicine (antimalarial).
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:392.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:391.1218178
Monoisotopic Mass:391.1218178
Topological Polar Surface Area:48.4
Heavy Atom Count:26
Complexity:406
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Unspecified
Registered Holders
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Guilin Pharmaceutical Co., Ltd.
Active
China
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Chongqing Kangle Pharmaceutical Co., Ltd.
Active
China
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