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Clopamide

Clopamide structure

CAS No:
636-54-4
Formula:
C14H20ClN3O3S
Chemical Name:
Clopamide
Synonyms:
Benzamide,3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-,rel-;Benzamide,4-chloro-N-(2,6-dimethylpiperidino)-3-sulfamoyl-,cis-;Benzamide,3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)-,cis-;rel-3-(Aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]benzamide;4-Chloro-N-(cis-2,6-dimethylpiperidino)-3-sulfamoylbenzamide;N-(cis-2′,6′-Dimethyl-1′-piperidyl)-3-sulfamyl-4-chlorobenzamide;Brinaldix;Chlosudimeprimyl;Clopamide;Clopamidum;Adurix;Aquex;DT 327
Categories:
Analytical Chemistry > Standard

Description

White or almost white, hygroscopic, crystalline powder

4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide is a sulfonamide.|Clopamide is an oral diuretic agent with antihypertensive activity. Like thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure.|Clopamide is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity. Clopamide appears to work in a similar manner as the thiazide diuretics and has a similar potency as chlorothiazide and hydrochlorothiazide.|A sulfamoylbenzamide piperidine. It is considered a thiazide-like diuretic.

Clopamide Basic Attributes

Molecular Weight：

345.84

Exact Mass：

345.84

EC Number：

211-261-7

UNII：

17S83WON0I

DSSTox ID：

DTXSID1022847

NCI Thesaurus Code：

C81074

ATC Code：

C - Cardiovascular system

HScode：

2935009090

Characteristics

PSA：

101

XLogP3：

1.59

Appearance：

White to yellowish crystalline powder

Density：

1.4±0.1 g/cm3

Melting Point：

248-249℃

Refractive Index：

1.613

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

42/43

safety instructions：

RTECS Number：

CV2338875

Marks：

Precautionary statement(s)：

P261-P280-P284-P304 + P340-P342 + P311

Hazard Statements：

H317-H334

GHS Classification：

|Danger|H317 (92.86%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 42 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

MeSH Entry Terms：

Brinaldix

Clopamide Use and Manufacturing

Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only.

Computed Properties

Molecular Weight:345.8
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:345.0913904
Monoisotopic Mass:345.0913904
Topological Polar Surface Area:101
Heavy Atom Count:22
Complexity:498
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes