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Metformin

Metformin structure

CAS No:
657-24-9
Formula:
C4H11N5
Chemical Name:
Metformin
Synonyms:
Imidodicarbonimidic diamide,N,N-dimethyl-;Biguanide,1,1-dimethyl-;N,N-Dimethylimidodicarbonimidic diamide;N,N-Dimethylbiguanide;N1,N1-Dimethylbiguanide;1,1-Dimethylbiguanide;N,N-Dimethyldiguanide;Flumamine;Metformin;NNDG;Dimethylbiguanide;DMGG;Fluamine;Gliguanid;Haurymelin;Metiguanide;Siofor;N′-Dimethylguanylguanidine;Metphage;Ficonax;Emiphage;Cidophage;Glucofine;Glifor;1-[Amino(dimethylamino)methylidene]guanidine;1-Carbamimidamido-N,N-dimethylmethanimidamide;[[Amino(dimethylamino)methylidene]amino]methanimidamide;Okamet
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin can cross the blood-brain barrier and triggers autophagy[1].

Metformin Basic Attributes

Molecular Weight：

129.16

Exact Mass：

129.16

EC Number：

211-517-8

Characteristics

PSA：

91.5

XLogP3：

-1.3

Appearance：

Solid

Density：

1.3±0.1 g/cm3

Melting Point：

199-200 °C

Boiling Point：

224.1ºC at 760 mmHg

Flash Point：

58.1±22.6 °C

Refractive Index：

1.576

Water Solubility：

Freely soluble as HCl salt

Storage Conditions：

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 deg C. Storage class (TRGS 510): Non Combustible Solids. /Metformin hydrochloride/

Vapor Pressure：

7.58X10-5 mm Hg at 25 deg C (est)

Toxicity：

LD50 oral in mouse: 1450mg/kg

PKA：

12.4None

Safety Information

Stability/Shelf Life：

Stable under recommended storage conditions. /Metformin hydrochloride/

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Metformin Use and Manufacturing

non-insulin dependent diabetes mellitus

Computed Properties

Molecular Weight:129.16
XLogP3:-1.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:129.10144537
Monoisotopic Mass:129.10144537
Topological Polar Surface Area:91.5
Heavy Atom Count:9
Complexity:132
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Improve glucose tolerance in patients with type 2 diabetes, lower basal and postprandial blood sugar; reduce liver glucose production, reduce intestinal glucose absorption, and improve insulin sensitivity by increasing peripheral blood glucose absorption and utilization.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pioglitazone Metformin Tablets (15mg/500mg)
Indication	Be careful when using with the following drugs: midazolam, gemfibrozil, rifampicin, furosemide, nifedipine, cationic drugs eliminated by renal tubular secretion (such as amiloride, digoxin, morphine, procainamide, quinadine, quinine, ranitidine, ampheniramine, trimethoprim, vancomycin). The following drugs may cause failure of blood sugar control: diuretics, steroids, phenothiazines, thyroid preparations, estrogen and oral contraceptives, phenytoin, niacin, sympathomimetic agents, calcium channel blockers, isoniazid.
Specifications	Each tablet contains 15 mg of pioglitazone hydrochloride (calculated as pioglitazone) and 500 mg of metformin hydrochloride
Manufacturer	Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

Linagliptin Metformin Tablets (Ⅱ) (Oushuangning)
Specifications	7s*2 plates (film coating)

Repaglinide Metformin Tablets (Ⅰ)
Ingredients	Repaglinide metformin.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each tablet contains 1 mg of repaglinide and 0.5 g of metformin hydrochloride
Manufacturer	Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

See More Related Drugs

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