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Clofenamide

Clofenamide structure

CAS No:
671-95-4
Formula:
C6H7ClN2O4S2
Chemical Name:
Clofenamide
Synonyms:
1,3-Benzenedisulfonamide,4-chloro-;m-Benzenedisulfonamide,4-chloro-;4-Chloro-1,3-benzenedisulfonamide;Aponiere;Aquedux;4-Chloro-m-benzenedisulfonamide;Clofenamide;Haflutan;4-Chlorobenzene-1,3-disulfonamide;Monochlorphenamide;Saltron;Salco;Soluran;Clofenamidum;Diuretic 2822;Eleklin;Frictan;Salzen;Indigatin;Macashi;Diumide;DS (pharmaceutical)
Categories:
Active Pharmaceutical Ingredients > Urinary System Drugs

Description

Clofenamide is an organic molecular entity.|Clofenamide is a benzenedisulfonamide-based agent and carbonic anhydrase (CA) inhibitor with diuretic activity. Clofenamide inhibits CA, thereby preventing sodium, bicarbonate and thus water reabsorption in the proximal convoluted tubule resulting in diuresis.

Clofenamide Basic Attributes

Molecular Weight：

270.71

Exact Mass：

270.71

EC Number：

211-588-5

UNII：

582ILN204B

DSSTox ID：

DTXSID4046153

NCI Thesaurus Code：

C77559

ATC Code：

C - Cardiovascular system

HScode：

2935009090

Characteristics

PSA：

137

XLogP3：

3.19700

Density：

1.699g/cm3

Melting Point：

207 °C

Boiling Point：

551.6ºC at 760 mmHg

Flash Point：

287.4ºC

Refractive Index：

1.627

Drug Information

MeSH Entry Terms：

diumide

Clofenamide Use and Manufacturing

Uses

Clofenamide is used as a diuretic agent.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:270.7
XLogP3:-0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:269.9535767
Monoisotopic Mass:269.9535767
Topological Polar Surface Area:137
Heavy Atom Count:15
Complexity:421
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes