Procyclidine hydrochloride
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Procyclidine hydrochloride
structure -
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CAS No:
1508-76-5
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Formula:
C19H29NO.ClH
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Chemical Name:
Procyclidine hydrochloride
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Synonyms:
1-Pyrrolidinepropanol,α-cyclohexyl-α-phenyl-,hydrochloride (1:1);1-Pyrrolidinepropanol,α-cyclohexyl-α-phenyl-,hydrochloride;1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol hydrochloride;Kemadrin hydrochloride;Tricyclamol hydrochloride;Procyclidine hydrochloride;Kemadrin;(±)-Procyclidine hydrochloride;Osnervan;Arpicolin;1-Cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol hydrochloride;30953-84-5
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CAS No:
Description
Procyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties.
A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
Procyclidine hydrochloride Basic Attributes
323.9
323.20200
216-141-8
757293
DTXSID8045357
2933990090
Characteristics
23.5
4.68030
White powder
159-164 °C
433.5°C at 760 mmHg
205.7ºC
In water, 8.59 mg/L at 25 deg C (est)
2-8°C
1.22X10-7 mm Hg at 25 deg C (est)
171.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
20/21/22
36
UY1926000
Xn
P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)|Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)
Arpicolin
Procyclidine hydrochloride Use and Manufacturing
An anticholinergic drug used in the treatment parkinson’s disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:323.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:323.2015923
Monoisotopic Mass:323.2015923
Topological Polar Surface Area:23.5
Heavy Atom Count:22
Complexity:301
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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