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Tyrothricin

Tyrothricin structure

CAS No:
1404-88-2
Chemical Name:
Tyrothricin
Synonyms:
Tyrothricin;Bactratycin;Intraderm tyrothricin;Tyroderm;Hydrotricine;Martricin;Tyrozets;Solutricine;Coltirot;Dermotricine;Tyri 10;1407-61-0;8001-01-2;9074-34-4
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

White or almost white powder.An antibiotic produced by growth of Bacillus brevis. It consists of a mixture of antibiotics, principally gramicidin and tyrocidine. Gramicidin is the more active component. Use is generally limited to local external applications. It is active against some Gram-positive bacteria, including species of pneumococci, streptococci, and staphylococci.

Tyrothricin Basic Attributes

Molecular Weight：

179.17112

Exact Mass：

1227.63000

EC Number：

215-771-0

Characteristics

PSA：

380

XLogP3：

5.10700

Density：

1.32g/cm3

Boiling Point：

1516.6ºC at 760mmHg

Flash Point：

871ºC

Refractive Index：

1.635

Water Solubility：

H2O: Insoluble

Toxicity：

LD50 in mice (mg/kg): >1500 s.c.; 100 i.p.; >3000 orally (Sous)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

YP2975000

Tyrothricin Use and Manufacturing

Tyrothricin is a complex of two unrelated peptide families, gramicidin complex and tyrocidines complex, produced by Bacillus brevis and discovered by Dubos in 1939. Typically, tyrothricin is composed of 20% of the linear pentadecylpeptide gramicidins and 80% of cyclic decapeptide tyrocidines. Both the gramicidins and tyrocidines act by disrupting bacterial cell wall integrity, but by differing mechanisms. Tyrothricin is used clinically for bacterial skin infections in some countries.

Drug Function and Efficacy

It is a polypeptide antibiotic with a broad antibacterial spectrum.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dequalinium gram bacterium lozenges
Ingredients	Each tablet contains 0.25 mg of dequalinamide and 1 mg of gramicidin.
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	Dequalinium chloride 0.25 mg and gramicidin 1 mg

Dequalinium gram bacterium lozenges
Ingredients	Each tablet contains 0.25 mg of dequalinamide and 1 mg of gramicidin.
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	Dequalinium chloride 0.25 mg and gramicidin 1 mg

Registered Holders

XELLIA PHARMACEUTICALS LTD.

European Union
Active
GIST-BROCADES NV PHARMACEUTICALS

United States
Inactive
BAXTER LABS INC DIV TRAVENOL LABS INC

United States
Inactive

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