7,14-Methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-, sulfate (1:1)
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![7,14-Methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-, sulfate (1:1) structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/464e8b527c2a4bd592f04bec6f181ef9.png "7,14-Methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-, sulfate (1:1)")
7,14-Methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-, sulfate (1:1)
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CAS No:
299-39-8
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Formula:
C15H26N2.H2O4S
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Chemical Name:
7,14-Methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-, sulfate (1:1)
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Synonyms:
7,14-Methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine,dodecahydro-,(7S,7aR,14S,14aS)-,sulfate (1:1);Sparteine,sulfate (1:1);7,14-Methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine,dodecahydro-,[7S-(7α,7aα,14α,14aβ)]-,sulfate (1:1);Sparteine sulfate;Sparm;Sparteal;Tocosimplex;Spartepur;Spartin;Spartocin;Spatym;Spal;Spareng;NSC 143087;NSC 26253;NSC 402663;(-)-Sparteine sulfate
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Off-White to Pale Yellow Solid
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
7,14-Methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-, sulfate (1:1) Basic Attributes
332.46
332.176971
206-078-4
Drug Information
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157) (See all compounds classified as Oxytocics.)
alpha Isosparteine
7,14-Methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-, sulfate (1:1) Use and Manufacturing
A class 1a antiarrhythmic agent; a sodium channel blocker.
Computed Properties
Molecular Weight:332.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Exact Mass:332.17697855
Monoisotopic Mass:332.17697855
Topological Polar Surface Area:89.5
Heavy Atom Count:22
Complexity:344
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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7,14-Methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-, sulfate (1:1)
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