 Home > Encyclopedia > Flumethasone pivalate

Flumethasone pivalate

Flumethasone pivalate structure

CAS No:
2002-29-1
Formula:
C27H36F2O6
Chemical Name:
Flumethasone pivalate
Synonyms:
Pregna-1,4-diene-3,20-dione,21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-,(6α,11β,16α)-;Pregna-1,4-diene-3,20-dione,6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-,21-pivalate;Pivalic acid,21-ester with 6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione;(6α,11β,16α)-21-(2,2-Dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione;6α,9α-Difluoro-16α-methylprednisolone 21-pivalate;6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-pivalate;Flumethasone pivalate;Locacorten;Locorten;Flumetasone pivalate;Flumethasone 21-pivalate;Lorinden;Flumetasone 21-pivalate;NSC 107680;Losalen
Categories:
Analytical Chemistry > Standard

Description

White or almost white, crystalline powder.

Solid

Flumethasone pivalate is a pivalate ester, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug and an antipruritic drug. It derives from a flumethasone.

Flumethasone pivalate Basic Attributes

Molecular Weight：

494.57

Exact Mass：

494.57

EC Number：

217-901-1

UNII：

0DV09X6F21

DSSTox ID：

DTXSID7049005

HScode：

2937220000

Characteristics

PSA：

100.90000

XLogP3：

3.44070

Appearance：

Solid

Density：

1.27g/cm3

Melting Point：

219 °C (base only)

Boiling Point：

600.3ºC at 760mmHg

Flash Point：

316.8ºC

Refractive Index：

1.55

Water Solubility：

dioxane: soluble 4.0ML, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane)

Vapor Pressure：

6.51E-17mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

22-36

RTECS Number：

TU3832010

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H351

GHS Classification：

|Warning|H351 (90.48%): Suspected of causing cancer [Warning Carcinogenicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 42 companies from 5 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

MeSH Entry Terms：

Cerson

Flumethasone pivalate Use and Manufacturing

Uses

topical anti-inflammatory corticosteroid

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:494.6
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:494.24799519
Monoisotopic Mass:494.24799519
Topological Polar Surface Area:101
Heavy Atom Count:35
Complexity:1030
Defined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Flumethasone pivalate

Shaanxi Cuikang Pharmaceutical Technolog Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Cosmetics raw materials,Pesticide intermediate,Photoelectric material,pharmaceutical intermediates,Raw materials for food and health products,Polymer materials,Fine Chemicals,Synthetic customization

Flumethasone 21-pivalate

CAS No.: 2002-29-1

Grade: Industrial Grade

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Flumethasone valerate CAS 2002-29-1

CAS No.: 2002-29-1

Grade: Pharmaceutical Grade

Content: 99%

Inquiry