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Nifenazone

Nifenazone structure

CAS No:
2139-47-1
Formula:
C17H16N4O2
Chemical Name:
Nifenazone
Synonyms:
3-Pyridinecarboxamide,N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-;Nicotinamide,N-antipyrinyl-;N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-pyridinecarboxamide;N-Antipyrinylnicotinamide;Nicodone;Nicofesone;Nicophesone;Nicophezon;Nicopyron;4-Nicotinamido-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;Nicotinic acid 4-antipyrilamide;4-(Nicotinoylamino)antipyrine;Nifenazone;Phenicazone;Thylin;Nifenazon;Nicazane;Niapyrin;Nicotinoylantipyrine;Nicoreumal;Nicoron;Nicotazone;Nicozone;Nikodon;Nikofezon;Nicodon;Niprazine;N-Nicotinoylaminoantipyrine;Dolongan;Reupiron
Categories:
Analytical Chemistry > Standard

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Description

Nifenazone is a pyrazole drug which can be used in the in the treatment of a variety of rheumatic disorders.

Nifenazone is a ring assembly and a member of pyrazoles.

Nifenazone Basic Attributes

Molecular Weight：

308.33

Exact Mass：

308.33

EC Number：

218-387-1

UNII：

8780F0K71U

NSC Number：

758411

DSSTox ID：

DTXSID7045366

ATC Code：

M - Musculo-skeletal system|N - Nervous system

HScode：

2933990090

Characteristics

PSA：

65.5

XLogP3：

2.20470

Density：

1.33g/cm3

Melting Point：

253 °C

Refractive Index：

1.671

Water Solubility：

45.2 [ug/mL]

Storage Conditions：

2-8°C

Collision Cross Section：

172.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

QS4005000

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

N-antipyrinylnicotinamide

Nifenazone Use and Manufacturing

analgesic, antiinflammatory

Computed Properties

Molecular Weight:308.33
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:308.12732577
Monoisotopic Mass:308.12732577
Topological Polar Surface Area:65.5
Heavy Atom Count:23
Complexity:511
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes