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Home > Encyclopedia > Dexamethasone 21-isonicotinate

Dexamethasone 21-isonicotinate

pharmaceutical raw materials
Dexamethasone 21-isonicotinate structure

Dexamethasone 21-isonicotinate 

structure
  • CAS No:

    2265-64-7

  • Formula:

    C28H32FNO6

  • Chemical Name:

    Dexamethasone 21-isonicotinate

  • Synonyms:

    Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-[(4-pyridinylcarbonyl)oxy]-,(11β,16α)-;Pregna-1,4-diene-3,20-dione,9-fluoro-11β,17,21-trihydroxy-16α-methyl-,21-isonicotinate;(11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-21-[(4-pyridinylcarbonyl)oxy]pregna-1,4-diene-3,20-dione;Isonicotinic acid,21-ester with 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione;HE 111;Dexamethasone isonicotinate;Isonicotinic acid dexamethasone-21 ester;Pyridine-4-carboxylic acid 21-dexamethasone ester;Dexamethasone 21-isonicotinate;Pyridine-4-carboxylic acid-(dexamethasone-21′)-ester;Voren;Auxiloson;Dexamethasone 21-(4-pyridinecarboxylate);Ketoren;Ausixone;Alin Depot;68402-70-0

  • Categories:

    Analytical Chemistry  >  Standard

Description

White or almost white crystalline powder.


Dexamethasone 21-(4-Pyridinecarboxylate) is a corticosteroid hormone.|Dexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, topically, and parenterally. Its unintended mineralocorticoid action may cause salt and water retention.|An anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause water and salt retention.

Dexamethasone 21-isonicotinate Basic Attributes

497.56

497.56

218-866-5

8LGC0BOA71

DTXSID3057690

Characteristics

113.79000

3.15540

1.34 g/cm3

250-252 °C

676ºC at 760 mmHg

362.6ºC

1.608

Practically insoluble in water, slightly soluble in anhydrous ethanol and in acetone.

2-8°C

Safety Information

P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P314, P322, P330, P363, P405, P501

H302+H312+H332

|Warning|H302+H312+H332 (33.33%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P314, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)|Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)|A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

Auxison

Dexamethasone 21-isonicotinate Use and Manufacturing

Uses

Dexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, topically, and parenterally. Its unintended mineralocorticoid action may cause salt and water retention.

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:497.6
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:497.22136590
Monoisotopic Mass:497.22136590
Topological Polar Surface Area:114
Heavy Atom Count:36
Complexity:1040
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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