(-)-Menthol
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(-)-Menthol
structure -
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CAS No:
2216-51-5
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Formula:
C10H20O
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Chemical Name:
(-)-Menthol
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Synonyms:
Cyclohexanol,5-methyl-2-(1-methylethyl)-,(1R,2S,5R)-;Menthol,(1R,3R,4S)-(-)-;Cyclohexanol,5-methyl-2-(1-methylethyl)-,[1R-(1α,2β,5α)]-;(1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexanol;l-Menthol;(-)-Menthol;(R)-(-)-Menthol;(-)-Menthyl alcohol;(1R)-(-)-Menthol;(1R,2S,5R)-(-)-Menthol;Levomenthol;l-(-)-Menthol;1R-Menthol;NSC 62788;L-Menthol;(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol;(1R,2S,5R)-2-Isopropyl-5-methylcyclohexan-1-ol;L-Mentholum;(-)-(1R,3R,4S)-Menthol;Minclea;(1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexanol;A 10474;(1R,2S,5R)-2-Isopropyl-5-methylcyclohexan-1-ol;Hakkano;(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol;(-)-trans-p-Menthan-cis-3-ol;FEMA 2665;98167-53-4;95650-44-5
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CAS No:
Description
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].
Characteristics
20.23000
3
D,l-menthol is a white crystalline solid with a peppermint odor and taste. (NTP, 1992)
0.890 g/cm3
41-43 °C
212 °C
93ºC
1.46
H2O: 0.49 mg/mL at 25 °C
-20ºC
0.8 mm Hg ( 20 °C)
5.4 (NTP, 1992) (Relative to Air)
LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rabbit > 5000 mg/kg
Peppermint odor
Peppermint taste
Safety Information
NONH for all modes of transport
2
R36/37/38; R41
S26-S37/39
OT0700000
Xi
Stable.
P261-P280-P305 + P351 + P338
H315-H318-H335
(-)-Menthol Use and Manufacturing
Both menthol and racemic menthol can be used as flavoring agents for toothpaste, perfume, beverages and candies. It is used as a stimulant in medicine, acting on the skin or mucous membranes, and has the effect of cooling and relieving itching; orally, it can be used as an anti-wind medicine for headache and inflammation of the nose, throat, and throat. Its esters are used in perfumes and medicines. In the world, my country and Brazil are the main natural mint producers, and the annual output of mint oil both reaches 2000-3000t. The main component of peppermint oil. Because of its unique mint flavor and cooling effect, it is widely used in candy, cosmetics and toothpaste.
Drug Function and Efficacy
Can relieve local pain
Registered Holders
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BASF SE
Active
Denmark
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FREY + LAU GMBH
Active
European Union
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SYMRISE AG
Active
European Union
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