Oxypurinol
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Oxypurinol
structure -
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CAS No:
2465-59-0
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Formula:
C5H4N4O2
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Chemical Name:
Oxypurinol
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Synonyms:
1H-Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione;4H-Pyrazolo[3,4-d]pyrimidine-4,6(5H)-dione,1,7-dihydro-;Alloxanthine;Oxipurinol;Oxypurinol;4,6-Dihydroxypyrazolo[3,4-d]pyrimidine;Oxoallopurinol;1H-Pyrazolo[3,4-d]pyrimidin-4,6-diol;BW 55-5;1H,3H,9H-Alloxanthine;4,6-Dioxopyrazolo[3,4-d]pyrimidine;NSC 76239;Oxyprim;1H,4H,5H,6H,7H-Pyrazolo[3,4-d]pyrimidine-4,6-dione;4318-51-8;16220-06-7;22767-93-7
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CAS No:
Description
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout[1].
Solid
Alloxanthine is a pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6. It has a role as an EC 1.17.3.2 (xanthine oxidase) inhibitor and a drug metabolite.|Oxypurinol, an inhibitor of xanthine oxidase, is a metabolite of allopurinol.|A xanthine oxidase inhibitor.
Oxypurinol Basic Attributes
152.11
152.11
139956
219-570-9
G97OZE5068
76239
DTXSID4035209
2933990090
Characteristics
82.6
-0.9
Light yellow Powder
2.19g/cm3
>300 °C @ Solvent: Water
662.9ºC at 760 mmHg
354.7ºC
1.989
soluble in DMSO.
-20°C Freezer
3.5E-18mmHg at 25°C
126.7 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|120.1 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]
Safety Information
IRRITANT
NONH for all modes of transport
3
36/37/38
36
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (97.56%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Intended for the treatment of congestive heart failure and hyperuricemia.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
23.3 +/- 6.0 hours
Oxypurinol inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid. Elevated concentrations of oxypurine and oxypurine inhibition of xanthine oxidase through negative feedback results in a decrease in the concentrations of uric acid in the blood and urine. Oxypurinol also facilitates the incorporation of hypoxanthine and xanthine into DNA and RNA, resulting in further reductions of serum uric acid concentrations.
Alloxanthine
Computed Properties
Molecular Weight:152.11
XLogP3:-0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Exact Mass:152.03342538
Monoisotopic Mass:152.03342538
Topological Polar Surface Area:86.9
Heavy Atom Count:11
Complexity:217
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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