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Prednisolone 21-hemisuccinate

Prednisolone 21-hemisuccinate structure

CAS No:
2920-86-7
Formula:
C25H32O8
Chemical Name:
Prednisolone 21-hemisuccinate
Synonyms:
Pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-,(11β)-;Pregna-1,4-diene-3,20-dione,11β,17,21-trihydroxy-,21-(hydrogen succinate);(11β)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione;Δ1-Hydrocortisone 21-hemisuccinate;Prednisolone hemisuccinate;Prednisolone 21-hemisuccinate;Prednisolone succinate;Prednisolone bisuccinate;Prednisolone 21-succinate;Prednisolut;Prednisolone 21-O-β-carbonylpropionic acid;1783-83-1
Categories:
Analytical Chemistry > Standard

Description

Prednisolone hemisuccinate is a synthetic glucocorticoid, a derivative of cortisol, which is used to treat a variety of inflammatory and auto-immune conditions.

Prednisolone succinate is a hemisuccinate resulting from the formal condensation of the 21-hydroxy group prednisolone with one of the carboxy groups of succinic acid. It is used to treat mild to moderate non-infectious eye allergies and inflammation, including damage caused by chemical and thermal burns. It has a role as an anti-inflammatory drug. It is a hemisuccinate, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It derives from a prednisolone and a succinic acid. It is a conjugate acid of a prednisolone succinate(1-).

Prednisolone 21-hemisuccinate Basic Attributes

Molecular Weight：

460.52

Exact Mass：

460.52

EC Number：

220-861-8

UNII：

G7080T74ON

DSSTox ID：

DTXSID1048964

HScode：

2937290000

Characteristics

PSA：

138.20000

XLogP3：

1.97330

Density：

0,86 g/cm3

Melting Point：

206.5-209.5 °C

Boiling Point：

358 °C400 mm Hg(lit.)

Flash Point：

265°C/15mm

Refractive Index：

1.6

Collision Cross Section：

210.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

61-40

safety instructions：

53-22-36/37/39-45

RTECS Number：

TU4153400

Precautionary statement(s)：

P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H360 (92.59%): May damage fertility or the unborn child [Danger Reproductive toxicity]|P201, P202, P260, P281, P308+P313, P314, P405, and P501|Aggregated GHS information provided by 28 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

MeSH Entry Terms：

prednisolone 21-succinate sodium

Prednisolone 21-hemisuccinate Use and Manufacturing

neuroleptic

Computed Properties

Molecular Weight:460.5
XLogP3:1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:460.20971797
Monoisotopic Mass:460.20971797
Topological Polar Surface Area:138
Heavy Atom Count:33
Complexity:950
Defined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Latest News on Prednisolone 21-hemisuccinate

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Prednisolone sodium succinate Formula

1715-33-9
Prednisolone 21-diethylaminoacetate Formula

5626-34-6
Aldosterone 21-hemisuccinate Formula

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Prednisolone sodium phosphate Structure

125-02-0
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1807-14-3
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Guide of Prednisolone 21-hemisuccinate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Latest News
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Prednisolone 21-hemisuccinate

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