4-Pyrimidinamine,5-(bromomethyl)-2-methyl-,monohydrobromide

S4. Add 100 grams of ring-closing product to a 1-liter jar.Slowly add 500 ml of 33percent HBr/HOAc solution.Slowly warm the system to 100°C, Maintain this temperature for 8-16 hours, TLC determines the endpoint of the reaction.After the reaction is completed, 20 grams of acidic activated carbon is added while hot, and the mixture is stirred for 30 minutes and then filtered. The filtrate is concentrated under pressure and dried to dryness. 30 milliliters of anhydrous ethanol is added, and the crystals are cooled and filtered.149 g of the target product was dried to give a yield of 87percent.2-methyl-5-ethoxymethyl-6-aminopyrimidine (1.1 g, 6.6 mmol) was fed to a 200 mL one-neck flask, and then a HBr solution in acetic acid (10percent, 73 mL) was added, heated to 100°C., and reacted for 2 hrs. The reaction was cooled to room temperature (where during the reaction, the solid was dissolved first, and then a solid was produced gradually). The reaction solution was suctioned, washed with diethyl ether, and recrystallized twice in methanol/anhydrous diethyl ether, to obtain a white solid (1.5 g, yield 81percent).

A pyrimidine derivative as G protein-coupled receptor kinase (GRK) inhibitor.