1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE

Yellow Solid

At room temperature, 6 (152.5 g, 893.7 mmol) was added dropwise to a solution of aluminium chloride (119.0 g, 893.7 mmol) in dichlorobenzene (120 mL). The reaction mixture was stirred at 100 °C for 5 h. After cooling to room temperature, dichloromethane was added and the resulting mixture was poured into H1-methyl-3-cyanoquinoline salt as a photosensitizer, cobalt oxime complex 2 as a cobalt catalyst, 5mL of acetonitrile was added2.69 mg (1 × 10 -2 mmol) of photosensitizer and 2.80 mg (6 × 10 -3 mmol) of cobalt catalyst were charged, the atmosphere was replaced with Ar atmosphere, and then0.2 mmol of 3'-chloroacetophenone (R1 is COCH3, R3 is Cl, R2, R4 are independently H) and 2 mmol of H2O are added. Room temperature, high pressureMercury lamp irradiation 5h. After the reaction was completed, the H2 production was detected by GC (TCD) and the conversion of benzene by GC (FID), Then over the column points. Nuclear magnetic resonance spectroscopy and mass spectrometry identification of broad-based as 3 '- chloro -2_ hydroxyacetophenone, 3' - chloro -4_ light base acetophenone and 3 '- chloro-6_Hydroxyacetophenone.The conversion of 3'-chloroacetophenone was 43percent. The conversion of 3'-chloro-2-hydroxyacetophenone, 3'-chloro-4-hydroxyacetophenone and 3'-chloro-6-hydroxyacetophenone The yields were 6percent, 2percent and 34percent respectively, and the H2 yield was 42percent.2-Chlorophenol (19.2 g, 150.0 mmol) was added to a 500.0 mL three-necked round bottom flask, and acetyl chloride (12.9 g, 165.0 mmol) was added dropwise at 0 C.After the completion of the dropwise addition, the mixture was stirred at room temperature for 2 hours.Then heat up to 130 C, Anhydrous aluminum trichloride (35.9 g, 270.0 mmol) was added to the round bottom flask.Stir for 2 hours. After the reaction, Carefully add water to quench the reaction, extract with ethyl acetate.After washing with water, saturated brine and dried over anhydrous sodium sulfate, Concentrate to give the crude product.

Molecular Weight:170.59
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:170.0134572
Monoisotopic Mass:170.0134572
Topological Polar Surface Area:37.3
Heavy Atom Count:11
Complexity:158
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes