Trimethylcolchicinic acid
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Trimethylcolchicinic acid
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CAS No:
3482-37-9
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Formula:
C19H21NO5
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Chemical Name:
Trimethylcolchicinic acid
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Synonyms:
Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-,(7S)-;Colchiceine,N-deacetyl-;Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-,(S)-;Colchicinic acid,O,O′,O′′-trimethyl-;(7S)-7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one;Trimethylcolchicinic acid;Deacetylcolchiceine;Desacetylcolchiceine;N-Deacetylcolchiceine;NSC 36796;(S)-7-Amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
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CAS No:
Description
Yellow-green Solid
7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one is a cyclic ketone.
Safety Information
NONH for all modes of transport
3
20/21/22
36
GH0960000
Xn
P280
H302-H312-H332
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Trimethylcolchicinic acid Use and Manufacturing
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization.Stimulates the intrinsic GTPase activity of tubulin.Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Computed Properties
Molecular Weight:343.4
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:343.14197277
Monoisotopic Mass:343.14197277
Topological Polar Surface Area:91
Heavy Atom Count:25
Complexity:623
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Latest News on Trimethylcolchicinic acid
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