3,5-Dibromo-4-methylpyridine
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3,5-Dibromo-4-methylpyridine
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CAS No:
3430-23-7
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Formula:
C6H5Br2N
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Chemical Name:
3,5-Dibromo-4-methylpyridine
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Synonyms:
Pyridine,3,5-dibromo-4-methyl-;4-Picoline,3,5-dibromo-;3,5-Dibromo-4-methylpyridine
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CAS No:
Safety Information
R20/21/22;R36/37/38
S26-S36/37/39
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (83.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
3,5-Dibromo-4-methylpyridine Use and Manufacturing
A solution of n-butyllithium in hexane (1.6 N, 16 ml) is added dropwise, under argon, to a solution of diisopropylamine (3.6 ml, 1.02 equiv.) in anhydrous THF (145 ml) maintained at -10 C. The reaction mixture is cooled to -78 C. and then a solution of 3, 5-dibromopyridine (5.92 g, 25 mmol) in THF (200 ml), cooled to -78 C., is added dropwise. The reaction mixture is stirred for 30 min and then methyl iodide (2.17 ml, 1.4 equiv.) is added dropwise. The stirring is maintained for 2 h at -78 C. A saturated aqueous NH4Cl solution (120 ml) is added. After evaporation of the solvents, the reaction mixture is extracted with EtOAc. The organic phase is washed with brine, dried over MgSO4 and evaporated. The yellow solid obtained is taken up with EtOAc. The suspension is filtered. The filtrate is evaporated and the residue is chromatographed on silica gel, elution being carried out with a petroleum ether/EtOAc (97.5/2.5) mixture. 1.67 g of product are obtained in the form of a white solid.To a mixture of l-(4-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2- yl)phenyl)pyrrolidin-2-one (1.30 g, 4.53 mmol), Embodiment 63 (S, E)-2-(2, 6-dimethoxy-4-(2-(4-methyl-5-phenylpyridin-3-yl)vinyl)benzylam ino)-3-hydroxypropanoic acid 63 Synthetic route Synthesis of compound 63-c Phenylboronic acid (385mg, 5.62mmol) and Embodiment 64 (S, E)-2-(4-(2-(5-(2, 3-Dihydrobenzo[b][1, 4]dioxin-6-yl)-4-methylpyridin-3-yl )vinyl)-2, 6-dimethoxybenzylamino)-3-hydroxypropanoic acid 64 Synthetic route Synthesis of compound 64-c 2, 3-Dihydrobenzo[b][1, 4]dioxin-6-phenylboronic acid (202mg, 1.12mmol) and
Computed Properties
Molecular Weight:250.92
XLogP3:2.6
Hydrogen Bond Acceptor Count:1
Exact Mass:250.87682
Monoisotopic Mass:248.87887
Topological Polar Surface Area:12.9
Heavy Atom Count:9
Complexity:87.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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