2-Amino-4-hydroxy-6-methylpyrimidine

white powder

2-amino-6-methylpyrimidin-4(3H)-one is a pyrimidone. It is a tautomer of a 2-amino-4-hydroxy-6-methylpyrimidine.

The above compound was prepared using a previously reportedmethod with minor modifications [26] as shown in Scheme 1. To asolution of guanidine (2.02 g, 33.84 mM) in acetone/ethanol mixture(1:2), a solution of acetoacetic ester (4.40 g, 33.86 mM) in acetone/ethanol was added dropwise and the resulting solution wasstirred at room temperature for 10 h. The solid product obtainedwas separated by filtration and recrystallized from acetic acid toobtain colorless crystals.Yield: 1.36 g (52percent). 1H NMR (400 MHz, CDCl3, ppm), d: 11.09 (s, 1H, OH), 5.92 (s, 2H, NH2), 5.14 (s, 1H, Ar–H), 2.14 (s, 3H, Ar–CH3).13C NMR (100 MHz, CDCl3, ppm) d: 162.3, 161.1, 155.3, 102.5, 23.9.ESI-MS calc. for C5H7N3O [M+]: 125.06; found 126.07 [M++1].Added to the mixture obtained in step a)Amount of anhydrous methanol dissolved, Into guanidine hydrochloride 95.5g (1mol)Heated to 100 reflux 3h, The mixture of solvents evaporated to dryness, Add the right amount of distilled water to just dissolve, Let cool to room temperature, With 1mol / L dilute hydrochloric acid to adjust the PH value to 6.5, A solid precipitation, suction filtration, Rinse with deionized water, The resulting wet finished product is at a temperature of 60 ° CVacuum drying oven available 12h availableAbout 77.7 g of 2-amino-4-hydroxy-6-methylpyrimidine.The product is 2-amino-4-hydroxy-6-methylpyrimidine, Purity of 99percentYield 62.1percentTo a solution of compound 3 (0.16gm, 0.0013 mol) in toluene, phosphorous oxychloride (0.9 ml, 0.0104 mol) [15] was added and heated at 110 C for 30 min. The excess POCl3 was distilled offand gummy residue was poured in to ice cold water. Neutralizationwith NaHCO3 gave yellow solid which was recrystallized frommethanol.Diisopropyl 2-chloroethoxymethylphosphonate (15 mL, 62.5 mmol) was added to a mixture of

Anconite intermediate.

Molecular Weight:125.13
XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:125.058911855
Monoisotopic Mass:125.058911855
Topological Polar Surface Area:67.5
Heavy Atom Count:9
Complexity:204
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes