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Sulfachlorpyridazine

Sulfachlorpyridazine structure

CAS No:
80-32-0
Formula:
C10H9ClN4O2S
Chemical Name:
Sulfachlorpyridazine
Synonyms:
Benzenesulfonamide,4-amino-N-(6-chloro-3-pyridazinyl)-;Sulfanilamide,N1-(6-chloro-3-pyridazinyl)-;4-Amino-N-(6-chloro-3-pyridazinyl)benzenesulfonamide;BA 10370;N1-(6-Chloro-3-pyridazinyl)sulfanilamide;Consulid;Sonilyn;Sulfachlorpyridazine;6-Sulfanilamido-3-chloropyridazine;3-Chloro-6-sulfanilamidopyridazine;Bactolin;Renalsulfa;Sulfaclorazina;Sulfarene;Sulpirazina;Durasulf;Sulfochlorpyridazine;Nefrosul;Cosulid;Ciba 10370;63747-94-4
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria.

Sulfachloropyridazine is a sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine. It has a role as an antibacterial drug, an EC 2.5.1.15 (dihydropteroate synthase) inhibitor and a drug allergen. It is a sulfonamide, a member of pyridazines and an organochlorine compound.|A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.|Sulfachlorpyridazine is a broad spectrum sulfonamide antibiotic used in veterinary medicine and in the swine and cattle industries.

Sulfachlorpyridazine Basic Attributes

Molecular Weight：

284.72

Exact Mass：

284.72

EC Number：

201-269-9

UNII：

P78D9P90C0

NSC Number：

757858

DSSTox ID：

DTXSID9045265

NCI Thesaurus Code：

C76974

HScode：

2935009090

Characteristics

PSA：

106

XLogP3：

Appearance：

off-white to light yellow

Density：

1.588 g/cm3

Melting Point：

187 °C

Boiling Point：

559.7°C at 760 mmHg

Flash Point：

292.3ºC

Refractive Index：

1.6300 (estimate)

Water Solubility：

0.5 M NaOH: soluble50mg/mL

Storage Conditions：

0-6°C

Collision Cross Section：

158.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|156.9 Å² [M+H]+ [CCS Type: TW]|160.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]|171.7 Å² [M+Na]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

36/37

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H317

GHS Classification：

|Warning|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501|Aggregated GHS information provided by 44 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)|Substances capable of killing agents causing urinary tract infections or of preventing them from spreading. (See all compounds classified as Anti-Infective Agents, Urinary.)

MeSH Entry Terms：

Monosodium Salt Sulfachlorpyridazine

Sulfachlorpyridazine Use and Manufacturing

Methods of Manufacturing

Use maleic anhydride and hydrazine hydrate to react with hydrochloric acid to form 3, 6-dihydroxypyridazine, and then chlorinate with phosphorus trichloride to obtain 3, 6-dichloropyridazine. The product was obtained by condensation with the participation of potassium carbonate.

Uses

Antibacterial compound.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Computed Properties

Molecular Weight:284.72
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:284.0134744
Monoisotopic Mass:284.0134744
Topological Polar Surface Area:106
Heavy Atom Count:18
Complexity:365
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Maleic anhydride

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