3-Fluoro-4-methoxyphenol

20 g of 2 (0.11 mole) obtained above was dissolved in 200 ml of ethanol and 100 ml of 20percent of NaOH was added slowly. 3.2D3. 3-Fluoro-4-methoxy-phenolTo a solution of l-(3-fluoro-4-methoxyphenyl)ethanone (50g, 0.297mol) in dichloromethane (1.5L) was added mCPBA (10Og, 77percent) and the reaction mixture was refluxed for 42h. After cooling to room temperature, the reaction mixture was filtered. The filtrate was evaporated and the residue was taken up in 10percent NaOH solution (250ml) and refluxed for 4h. The reaction mixture was cooled and washed with diethyl ether (3x200ml). The aqueous phase was acidified with 1.5N HCl and the product was extracted with ethyl acetate (2x200ml). The combined organic layer was washed with water, brine and dried. EPO General procedure: To a flame-dried 25 mL round bottom flask was charged Activated Mg (7.5 mmol, 1.5 eq.) and 5 mL anhydrous THF. To this suspension was added 2 drops of 1, 2-dibromoethane. After 5 min, a solution of Aryl bromide (5 mmol, 1.0 eq.) in 5 mL anhydrous THF was slowly added to the suspension of Mg at room temperature. The reaction was mildly exothermic. The Grignard reagent was titrated and 1 mmol of this reagent was added to a flame-dried reaction vial. The solution was diluted with 3 mL anhydrous THF and after cooling to 0° C. in an ice bath, a solution of oxaziridine (1.5 mmol, 1.5 eq.) in 1 mL anhydrous THF was added. The ice bath was removed and the reaction was allowed to reach room temperature. After time t, the reaction was quenched with saturated aqueous NHA round bottom flask was charged with

Molecular Weight:142.13
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:142.04300762
Monoisotopic Mass:142.04300762
Topological Polar Surface Area:29.5
Heavy Atom Count:10
Complexity:108
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes