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Saccharin

Saccharin structure

CAS No:
81-07-2
Formula:
C7H5NO3S
Chemical Name:
Saccharin
Synonyms:
1,2-Benzisothiazol-3(2H)-one,1,1-dioxide;1,2-Benzisothiazolin-3-one,1,1-dioxide;Anhydro-o-sulfaminebenzoic acid;Benzoic sulfimide;Benzoic sulphinide;Benzosulfimide;o-Benzosulfimide;o-Benzoyl sulfimide;1,2-Dihydro-2-ketobenzisosulfonazole;2,3-Dihydro-3-oxobenzisosulfonazole;Garantose;Glucid;Gluside;Saccharin;Saccharin acid;550 Saccharine;Saccharin insoluble;Saccharinol;Saccharinose;Saccharol;o-Sulfobenzimide;o-Sulfobenzoic acid imide;Benzosulfinide;o-Benzoic sulfimide;Saccharine;3-Hydroxybenzisothiazole-S,S-dioxide;3-Benzisothiazolinone 1,1-dioxide;Saccharimide;o-Benzoic acid sulfimide;1,1-Dioxo-1,2-benzisothiazol-3(2H)-one;2,3-Dihydro-1,2-benzisothiazol-3-one-1,1-dioxide;NSC 5349;1,1-Dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazole;1,1-Dioxo-1,2-benzothiazol-3-one;Necta Sweet;Sucram;1,1-Dioxo-1,2-dihydro-1λ*6*-benzo[d]isothiazol-3-one;2,3-Dihydro-1λ6,2-benzothiazole-1,1,3-trione;Benzo[d]isothiazol-3(2H)-one-1,1-dioxide;126987-83-5;474-91-9;61255-27-4;890126-34-8
Categories:
Cosmetic Ingredient > Oral Care

Description

white crystalline solid Saccharin is a crystalline solid with a sweet taste (500 times sweeter than sugar). Saccharin occurs as odorless white crystals or a white crystalline powder. It has an intensely sweet taste, with a metallic or bitter aftertaste that at normal levels of use can be detected by approximately 25% of the population. The aftertaste can be masked by blending saccharin with other sweeteners.

Saccharin Basic Attributes

Molecular Weight：

183.18

Exact Mass：

183.18

BRN：

6888

EC Number：

201-321-0

HScode：

29251100

Characteristics

PSA：

71.6

XLogP3：

0.9

Appearance：

White Crystals or Crystalline Powder

Density：

0.828 g/cm³

Melting Point：

228.8-229.7 °C

Boiling Point：

299

Flash Point：

219.3±24.0 °C

Refractive Index：

1.714

Water Solubility：

H2O: 3.3 g/L (20 ºC);acetone: soluble 1g in 12mL(lit.)

Storage Conditions：

Refrigerator

Vapor Pressure：

1.03X10-7 mm Hg at 25 deg C (est)

Toxicity：

Oral-Mouse LD50; 17000 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

Odor：

ODORLESS OR HAS FAINT AROMATIC ODOR.

Taste：

In dilute aqueous solution it is 500 times as sweet as sugar; sweet taste detectable in 1:100,000 dilution.

PH：

pH of 0.35% aqueous solution: 2.0

Safety Information

Hazard category：

IRRITANT

Transport codes：

UN 3077 9/PG 3

wgk germany：

hazard class code：

40-62-63-68

safety instructions：

24/25

RTECS Number：

DE4200000

Marks：

Xn:Harmful

Storage features：

Ventilated, low temperature and dry

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, P501

Hazard Statements：

H302

Toxicity

Toxicity class：

practically nontoxic

Saccharin Use and Manufacturing

Methods of Manufacturing

See "02326, Sodium Saccharin" and the aforementioned "023.3.1".

Uses

Usually used in high performance liquid chromatographic method for the simultaneous separation and determination of acesulfame potassium, saccharine and aspartame;and also used in sweet preference test of rats.

Material

Sodium nitrite

Ammonia

Sodium hypochlorite

Copper sulfate

Downstream Products

Sodium saccharin dihydrate

Drug Function and Efficacy

This product is involved in the formation of bones and the reconstruction of bone tissue after fracture, as well as muscle contraction, nerve transmission, coagulation mechanism and reducing the permeability of capillaries.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

SACCHARINUM- saccharin_liquid
Manufacturer	Washington Homeopathic Products

Calcium Lactate Chewable Tablets
Ingredients	Each tablet of this product contains 0.3g of calcium lactate. The auxiliary materials are: sucrose, citric acid, saccharin, tartrazine, magnesium stearate, and lemon essence.
Indication	1. This product should not be used in combination with digitalis drugs. 2. Drinking large amounts of alcoholic and caffeinated beverages and smoking large amounts of cigarettes will inhibit the absorption of calcium. 3. Eating large amounts of fiber-rich foods can inhibit the absorption of calcium, because calcium combines with cellulose to form compounds that are not easily absorbed. 4. When this product is used in combination with phenytoin sodium and tetracyclines, the absorption of both is reduced. 5. Vitamin D, birth control pills, and estrogen can increase calcium absorption. 6. When aluminum-containing antacids are taken with this product, aluminum absorption increases. 7. When this product is used in combination with thiazide diuretics, hypercalcemia is likely to occur (due to increased renal tubular absorption of calcium).
Specifications	0.3g
Manufacturer	China Resources Double-Crane Pharmaceutical Co., Ltd.

Wumeirendan
Ingredients	Licorice, menthol, mint oil, dried plum extract, vitamins, citric acid, flavor, saccharin, sucrose, starch, gum arabic, sorbic acid, sodium benzoate
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each 10 pills weigh 0.7 grams

See More Related Drugs

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Food Sweeteners Saccharin Insoluble CAS 81-07-2

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Cas no. 81-07-2 Saccharin Mainly used for the production of pesticide intermediates and the production of sodium saccharin

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Saccharin

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Learn More Other Chemicals

Sodium saccharin dihydrate

6155-57-3
Sodium saccharin

128-44-9
Potassium saccharin

10332-51-1
Calcium saccharin Formula

6485-34-3
Ammonium saccharin Formula

6381-61-9
Calcium hydrogen phosphate dihydrate Formula

7789-77-7
Strontium dichloride hexahydrate Structure

10025-70-4
1-Tetradecanol, 1-(dihydrogen phosphate) Structure

10054-29-2
What is Disodium monofluorophosphate

10163-15-2
What is Sodium monofluorophosphate

7631-97-2

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Guide of Saccharin

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Use and Manufacturing
Material
Downstream Products
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
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Saccharin

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