3,4-Dihydro-5-hydroxy-2(1H)-quinolinone
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3,4-Dihydro-5-hydroxy-2(1H)-quinolinone
structure -
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CAS No:
30389-33-4
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Formula:
C9H9NO2
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Chemical Name:
3,4-Dihydro-5-hydroxy-2(1H)-quinolinone
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Synonyms:
2(1H)-Quinolinone,3,4-dihydro-5-hydroxy-;Carbostyril,3,4-dihydro-5-hydroxy-;3,4-Dihydro-5-hydroxy-2(1H)-quinolinone;5-Hydroxy-3,4-dihydrocarbostyryl;3,4-Dihydro-5-hydroxycarbostyril;5-Hydroxy-1,2,3,4-tetrahydro-2-quinolinone;5-Hydroxy-3,4-dihydrocarbostyril;5-Hydroxy-3,4-dihydro-2(1H)-quinolinone;5-Hydroxy-3,4-dihydro-1H-quinolin-2-one
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CAS No:
3,4-Dihydro-5-hydroxy-2(1H)-quinolinone Basic Attributes
163.17
163.17
BH76UU379C
DTXSID20184472
2933790090
Characteristics
49.3
0.7
light yellow crystal or powder
1.3±0.1 g/cm3
225-227ºC
381.2°C at 760 mmHg
184.3±27.9 °C
1.604
Safety Information
Xi: Irritant;
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
3,4-Dihydro-5-hydroxy-2(1H)-quinolinone Use and Manufacturing
To a 100 ml three-necked flask were added 3, 4, 7, 8-tetrahydro-2, 5 (1 H, 6Η) -quinoline dione (0.02 mol) and cyclohexane (25 ml) After stirring to dissolve in the ice bath for 10min, slowly add dropwise a solution of N-bromosuccinimide (0.03mol) in cyclohexane (5ml), and reflux for 3h at the end of the dropwise addition. After completion of the reaction by TLC, cool down to room temperature . Water was added (amount was 0.7 times the volume of the reactant), and the mixture was allowed to stand with stirring. The aqueous layer was extracted with ethyl acetate (1 × the volume of the aqueous layer 4 times), and the organic layers were combined. Anhydrous sulfuric acid Calcium was dried and filtered, the filtrate was evaporated to remove the solvent, and the residue was dried to give an off-white solid as a 5-hydroxy-Dihydro-2 (1H) -quinolone (Yield 92.7percent), mp 233 ~ 234 °C, BP2013-HPLC method chromatography purity 94.3percent.Preparation of 7-HQ in the Presence of a Salt; A 0.5 l reactor was charged with 3-MPCA (40 g, 0.185 mole), AlClPreparation of 7-HQ in a Mixture Containing a High Boiling Solvent; A 3.0 l reactor was charged with 3-MPCA (300 g, 1.4 mole), AlClPreparation of 7-HQ in a Melt; A 2.0 l reactor was charged with 3-MPCA (150 g, 0.69 mole) and AlCl
Carteolol (C184450) metabolite.
Computed Properties
Molecular Weight:163.17
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:163.063328530
Monoisotopic Mass:163.063328530
Topological Polar Surface Area:49.3
Heavy Atom Count:12
Complexity:193
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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3,4-Dihydro-5-hydroxy-2(1H)-quinolinone
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