3,3-Dimethyl-2-butanol

102.17500

102.17

207-347-9

939

Colorless, liquid

29051910

20.23000

1.41330

Clear colourless liquid

0.810 g/cm³ @ Temp: 25 °C

4.8 °C

120 °C

84 °F

n20/D 1.415(lit.)

Soluble inethanol, diethyl ether, water (25 g/L).

Keep tightly closed. Keep away from heat, sparks, and open flame. Store in a cool dry place.

8.81 mm Hg at 25 deg C (est)

Henry's Law constant = 1.76X10-5 atm-cu m/mol at 25 °C (est)

Hydroxyl radical reaction rate constant = 9.16X10-12 cu cm/molec-sec at 25 °C (est)

III

3

UN 1987 3/PG 3

3

R10

S16

EL2276000

P210, P233, P240, P241, P242, P243, P260, P280, P303+P361+P353, P314, P370+P378, P403+P235, P501

H226

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Observe all federal, state, and local environmental regulations.

|Warning|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P280, P303+P361+P353, P314, P370+P378, P403+P235, and P501

Engineering Controls: Safety shower and eye bath. Mechanical exhaust required.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.|Personal Protective Equipment - Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.

FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Specific Hazard(s): Flammable liquid. Vapor may travel considerable distance to source of ignition and flash back. Specific Method(s) of Fire Fighting: Use water spray to cool fire-exposed containers.|EXTINGUISHING MEDIA. Suitable: For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water.

Vapor may travel considerable distance to source of ignition and flash back. Container explosion may occur under fire conditions.

Procedure to be followed in case of leak or spill - Evacuate area. Shut off all sources of ignition. Personal precautions - Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. Methods for clean-up - Cover with dry-lime, sand, or soda ash. Place in covered containers using non-sparking tools and transport outdoors. Ventilate area and wash spill site after material pickup is complete.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Keep away from sources of ignition - no smoking. Keep container tightly closed in a cool well-ventilated place. Do not empty into drains. Take precautionary measures against static discharges.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.|In case of contact, immediately wash skin with soap and copious amounts of water.

May cause skin irritation. May cause eye irritation.

/AQUATIC SPECIES/ The aquatic toxicity of a secondary alcohol, 3,3-dimethyl-2-butanol (pinacolyl alcohol (PA)), was determined. Acute tests were conducted on Pimephales promelas, 48 hr EC50 = 443.1 mg PA/L, and Daphnia magna, 24 hr EC50 = 513.2 mg PA/L. Growth inhibition tests (96 hr) were conducted using Ankistrodesmus falcatus, EC50 = 257.7 mg PA/L. In general, the toxicity of straight-chained alcohols increases proportionally with the molecular weights. Using the structure activity equation (Log EC50 = 1.10 (LogP) + 0.05 (LogP)squared - 1.22) for P. promelas, the calculated toxicity of PA (EC50 = 547.0 mg/L) agrees with experimental determinations.

Pinacolyl alcohol is synthetically derived(1).

Pinacolyl alcohol's production and use as a synthetic precursor to chemical warfare agents(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 150(SRC), determined from a log Kow of 1.48(2)and a regression-derived equation(3), indicates that pinacolyl alcohol is expected to have high mobility in soil(SRC). Volatilization of pinacolyl alcohol from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 1.8X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(4). Pinacolyl alcohol is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 8.8 mm Hg(SRC) determined from a fragment constant method(5). Biodegradation data for pinacolyl alcohol were not available(SRC, 2009).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 150(SRC), determined from a log Kow of 1.48(2) and a regression-derived equation(3), indicate that pinacolyl alcohol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces may be important(3) based upon an estimated Henry's Law constant of 1.8X10-5 atm-cu m/mole(4) developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 53 hours and 19 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 2.8(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data for pinacolyl alcohol were not available(SRC, 2009).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), pinacolyl alcohol, which has an estimated vapor pressure of 8.8 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase pinacolyl alcohol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 42 hours(SRC), calculated from its rate constant of 9.2X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Pinacolyl alcohol does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of pinacolyl alcohol with photochemically-produced hydroxyl radicals has been estimated as 9.2X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 42 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Pinacolyl alcohol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Pinacolyl alcohol does not contain chromophores that absorb at wavelengths >290 nm(2) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 2.8 was calculated for pinacolyl alcohol(SRC)using a log Kow of 1.48(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of pinacolyl alcohol is estimated as 150(SRC), using a log Kow of 1.48(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that pinacolyl alcohol is expected to have high mobility in soil.

The Henry's Law constant for pinacolyl alcohol is estimated as 1.76X10-5 atm-cu m/mole at 25 °C(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that pinacolyl alcohol is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 53 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 19 days(SRC). Pinacolyl alcohol's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Pinacolyl alcohol is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 8.8 mm Hg(SRC), determined from a fragment constant method(3).

Occupational exposure to pinacolyl alcohol may occur through inhalation of vapor and dermal contact at workplaces where pinacolyl alcohol is produced or used. (SRC)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Higher alcohols (>3 carbons) and related compounds/|/SRP:/ Basic Treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Higher alcohols (>3 carbons) and related compounds/|/SRP:/ Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques, with a bag-valve-mask device, may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose strip or glucometer readings below 50 mg) and administer 50% dextrose if necessary ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Higher alcohols (>3 carbons) and related compounds/

3,3-dimethyl-2-butanol

2-Butanol, 3,3-dimethyl-: ACTIVE

Food additives -> Flavoring Agents

Flavoring Agents