(4S)-4-Methyl-2-oxazolidinone
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(4S)-4-Methyl-2-oxazolidinone
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CAS No:
4042-35-7
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Formula:
C4H7NO2
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Chemical Name:
(4S)-4-Methyl-2-oxazolidinone
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Synonyms:
(S)-4-Methyloxazolidin-2-one;(4S)-4-Methyl-2-oxazolidinone;(4S)-4-methyl-1,3-oxazolidin-2-one;(S)-4-METHYL-2-OXAZOLIDINONE;2-Oxazolidinone, 4-methyl-, (4S)-;(s)-4-methyl-2-oxazolidone;4beta-Methyloxazolidine-2-one;S-4-methyl-Oxazolidin-2-one;SCHEMBL1438915;CTK8E2721
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CAS No:
(4S)-4-Methyl-2-oxazolidinone Use and Manufacturing
General procedure: To a DMSO-dTriethylamine (0.94 mL, 6.65 mmol) was added dropwise to a solution of L- alaninol (500 mg, 6.65 mmol) and [1, ] 1-carbonyldiimidazole (1.29 g, 7.98 mmol) in dry THF (10 mL) at rt, under argon atmosphere. The reaction mixture was stirred overnight at [60°C.] The solvent was removed by evaporation under reduced pressure. Purification of the residue by silica gel column chromatography, eluting with 6percent methanol in dichloromethane, afforded the desired compound (450 mg, 67percent). Rf = 0.39 [(MEOH/CH2CL2] 6: 94). 1H NMR [(CDC13)] [S] 6.74 (m, 1H), 4.45-4. 34 (m, 1H), 4.98-4. 77 (m, 2H), 1.17 (m, 3H).
Computed Properties
Molecular Weight:101.10
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:101.047678466
Monoisotopic Mass:101.047678466
Topological Polar Surface Area:38.3
Heavy Atom Count:7
Complexity:91.7
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes