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Bromopride

Bromopride structure

CAS No:
4093-35-0
Formula:
C14H22BrN3O2
Chemical Name:
Bromopride
Synonyms:
Benzamide,4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxy-;o-Anisamide,4-amino-5-bromo-N-[2-(diethylamino)ethyl]-;4-Amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;N-Diethylaminoethyl-2-methoxy-4-amino-5-bromobenzamide;2-Methoxy-4-amino-5-bromo-N,N-diethylaminoethylbenzamide;Bromopride;Viadil;Emepride;Emoril
Categories:
Analytical Chemistry > Standard

Description

Bromopride is a dopamine antagonist with prokinetic properties， widely used as an antiemetic.

4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide is a member of benzamides.|Bromopride is a dopamine antagonist used as an antiemetic. Its prokinetic properties are similar to those of metoclopramide. It is unavailable in America or the United Kingdom.

Bromopride Basic Attributes

Molecular Weight：

344.25

Exact Mass：

344.25

EC Number：

223-842-2

UNII：

75473V2YZK

NSC Number：

758391

DSSTox ID：

DTXSID0045383

ATC Code：

A - Alimentary tract and metabolism

HScode：

2924299090

Characteristics

PSA：

67.6

XLogP3：

2.67

Density：

1.3±0.1 g/cm3

Melting Point：

149 °C

Boiling Point：

435.8±45.0 °C at 760 mmHg

Flash Point：

217.3±28.7 °C

Refractive Index：

1.565

Storage Conditions：

2-8°C

Collision Cross Section：

173.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

wgk germany：

hazard class code：

20/21/22

safety instructions：

RTECS Number：

BZ3280000

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Protein Binding：

40%.

Drug Information

Drug Indication：

Bromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the GI tract.

MeSH：

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)|Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

Absorption：

Renal, 10-14% as original compound.

Metabolism/Metabolites：

Hepatic.

MeSH Entry Terms：

bromoprid

Bromopride Use and Manufacturing

An antiemetic

Computed Properties

Molecular Weight:344.25
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:343.08954
Monoisotopic Mass:343.08954
Topological Polar Surface Area:67.6
Heavy Atom Count:20
Complexity:300
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Bromopride

CAS No.: 4093-35-0

Content: 99.00%

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