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Bromocyclopropane

Bromocyclopropane structure

CAS No:
4333-56-6
Formula:
C3H5Br
Chemical Name:
Bromocyclopropane
Synonyms:
Cyclopropane,bromo-;Bromocyclopropane;Cyclopropyl bromide;NSC 89692
Categories:
Organic Chemistry > Hydrocarbons and Derivatives

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Description

clear colourless liquid

Bromocyclopropane Basic Attributes

Molecular Weight：

120.98

Exact Mass：

120.98

BRN：

1900287

EC Number：

224-375-7

NSC Number：

89692

DSSTox ID：

DTXSID8063418

HScode：

29035990

Characteristics

PSA：

XLogP3：

1.5

Appearance：

Clear colorless Liquid

Density：

1.5052 g/cm³ @ Temp: 25 °C

Boiling Point：

69 °C

Flash Point：

20 °F

Refractive Index：

1.553

Water Solubility：

H2O: immiscible

Storage Conditions：

2-8°C

Safety Information

Packing level：

Ⅱ

Hazard category：

Transport codes：

UN 1993 3/PG 2

wgk germany：

hazard class code：

11-36/37/38

safety instructions：

16-26-36-37/39

Marks：

F,Xi

Hazard note：

Irritant

Stability/Shelf Life：

Stable at room temperature in closed containers under normal storage and handling conditions.

Precautionary statement(s)：

P210-P261-P305 + P351 + P338

Hazard Statements：

H225-H315-H319-H335

GHS Classification：

|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 50 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Bromocyclopropane Use and Manufacturing

Methods of Manufacturing

(1) Add 179 g of 1, 3-bromochloropropane to a three-necked flask, 29 g of potassium cyanide and 50 ml of water, and stirred while heating until dissolved.Further, 70 ml of an ethanol solution was added, and the mixture was stirred and refluxed for 2 hours.Cool to room temperature, dilute with 300 ml of water, and separate the oil and water layer.Extract and dry with 40 ml of chloroform and anhydrous calcium chloride.Chloronitrile 316.9g was obtained.In the produced chlorobutyronitrile 241.6gAdd 100 ml of sodium hydroxide solution, and add stirring reaction for 2 hours.Then add water 200ml, cooled to about 10 °C, add 44ml of concentrated sulfuric acid acidification reaction, extraction and extraction agent drying and drying, to obtain cyclopropionic acid 330.1g;The obtained cyclopropionic acid 324.8 was added dropwise to contain 48 g of oxidized mercury, 160ml of a mixed solution of 1, 1, 2, 2-tetrachloroethane and liquid bromine 64.4g, Stir well, after reacting for 2 hours, cool it to 5 ° C.Drying with a detergent and a desiccant to obtain 419.15 g of bromocyclopropane;The separation extractant used for separation and extraction of cyclopropionic acid 3 is petroleum ether.The desiccant is anhydrous sodium sulfate; the detergent and desiccant used for washing and drying the bromocyclopropane 4 are respectively tetrachloroethane and calcium chlorideUnder nitrogen, 220 ml of 1, 2-dichloroethane was added to the above reaction intermediate in a 500 mL three-necked flask and(0.44 mol) of trichlorobromomethane, and the mixture was stirred well. After the temperature was raised to 75C, a mixed solution of m-chloroperbenzoic acid dissolved in 1, 2-dichloroethane was added dropwise. During the addition, the solution was released from the gas, and the dropping speed was controlled in accordance with the amount of generation of the bubbles. After the completion of the reaction, the reaction was stirred for 3 hours while maintaining the temperature, and the starting material point was disappeared by TLC, and the reaction product was detected in the gas phase. After the reaction, the reaction mixture was quenched by adding aqueous sodium bisulfite solution, and the organic layer was separated and washed with saturated brine. After drying over anhydrous magnesium sulfate, the organic layer was heated to atmospheric distillation (rectification column length: 10 cm) 60-72 ° C to obtain crude liquid yellow liquid, re-distillation to collect 67-69 ° C distillate to be colorless and transparent liquid cyclopropyl bromide, GC: 99.5percent, HNMR structure.

Uses

Pharmaceutical intermediates.

Manufacturing Info：

Cyclopropane, bromo-: ACTIVE

Computed Properties

Molecular Weight:120.98
XLogP3:1.5
Exact Mass:119.95746
Monoisotopic Mass:119.95746
Heavy Atom Count:4
Complexity:22.5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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