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Mono(2-ethylhexyl) phthalate

Mono(2-ethylhexyl) phthalate structure

Mono(2-ethylhexyl) phthalate 

structure
  • CAS No:

    4376-20-9

  • Formula:

    C16H22O4

  • Chemical Name:

    Mono(2-ethylhexyl) phthalate

  • Synonyms:

    1,2-Benzenedicarboxylic acid,1-(2-ethylhexyl) ester;Phthalic acid,mono(2-ethylhexyl) ester;1,2-Benzenedicarboxylic acid,mono(2-ethylhexyl) ester;Phthalic acid,2-ethylhexyl ester;Mono(2-ethylhexyl) phthalate;2-Ethylhexyl hydrogen phthalate;BAR 1;Mono(ethylhexyl) phthalate;2-((2-(Ethyl)hexyloxy)carbonyl)benzoic acid;1,2-Benzenedicarboxylic acid,1-(2-ethylheptyl) ester;143451-17-6;2562357-53-1

  • Categories:

    Analytical Chemistry  >  Standard

Description

Phthalic acid mono-2-ethylhexyl ester (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17[1].


Mono(2-ethylhexyl)phthalate is a clear colorless to cloudy white viscous liquid. (NTP, 1992)|Solid


Mono(2-ethylhexyl)phthalate is a clear colorless to cloudy white viscous liquid. (NTP, 1992)|Mono(2-ethylhexyl) phthalate is the mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid. It derives from a 2-ethylhexan-1-ol. It is a conjugate acid of a mono(2-ethylhexyl) phthalate(1-).

Mono(2-ethylhexyl) phthalate Basic Attributes

278.34

278.34

224-477-1

DTXSID2025680

2922509090

Characteristics

63.6

4

Mono(2-ethylhexyl)phthalate is a clear colorless to cloudy white viscous liquid. (NTP, 1992)

1.1±0.1 g/cm3

25-27 °C

408.9°C at 760 mmHg

>93 °C

1.517

less than 1 mg/mL at 70° F (NTP, 1992)

Refrigerator

182.27 Ų [M+Na]+

Insoluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

MONO(2-ETHYLHEXYL)PHTHALATE may react exothermically with strong oxidizing agents. May also generate heat with caustic solutions. Flammable hydrgen is generated by mixing with alkali metals and hydrides. May be sensitive to prolonged exposure to light.

Safety Information

3

36/37/38-36/38

26-36/37/39

TI2500000

Xi

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

H315

This chemical is probably combustible. (NTP, 1992)

|Warning|H315 (97.44%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Drug Information

SYMPTOMS: Exposure to this compound may cause skin irritation. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits acrid smoke and irritating fumes. Combustion may result in the release of toxic gases. This compound is a skin irritant. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

MEHP

Mono(2-ethylhexyl) phthalate Use and Manufacturing

Phthalate metabolite, responsible for inducing apoptosis in germ and Sertoli cells by disrupting junction complexes.

Computed Properties

Molecular Weight:278.34
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:278.15180918
Monoisotopic Mass:278.15180918
Topological Polar Surface Area:63.6
Heavy Atom Count:20
Complexity:314
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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