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2,3-Difluoroaniline

2,3-Difluoroaniline structure

CAS No:
4519-40-8
Formula:
C6H5F2N
Chemical Name:
2,3-Difluoroaniline
Synonyms:
Benzenamine,2,3-difluoro-;Aniline,2,3-difluoro-;2,3-Difluorobenzenamine;2,3-Difluoroaniline;2,3-Difluorophenylamine
Categories:
Organic Chemistry > Organic Fluorine Compound

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Description

clear light orange liquid

2,3-Difluoroaniline Basic Attributes

Molecular Weight：

129.11

Exact Mass：

129.11

BRN：

2716500

EC Number：

224-847-2

DSSTox ID：

DTXSID80196415

HScode：

2921420090

Characteristics

PSA：

XLogP3：

1.4

Appearance：

Clear light orange Liquid

Density：

1.3±0.1 g/cm3

Boiling Point：

69 °C @ Press: 12 Torr

Flash Point：

160 °F

Refractive Index：

1.521

Storage Conditions：

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

2941

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

26-27-28-36/37/39-36

Marks：

Xn,Xi

Hazard note：

Irritant

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302 + H312 + H332-H315-H319-H335

GHS Classification：

|Danger|H302 (95.65%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P311, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2,3-Difluoroaniline Use and Manufacturing

Methods of Manufacturing

First, 0.638 g (2.01 mmol) of 1, 2-dibromo-4, 5-difluoro-3-nitrobenzene was dissolved in 4 mL of methanol, and then 48.4 mg of 10percent Pd/C (50percent wet) and 6.2 mg (0.06 mmol) of triethylamine were added. The atmosphere inside the reaction vessel was substituted with hydrogen, and the reaction mixture was reacted at 50°C for 2 hours under slight hydrogen pressurization. Analysis of the resulting reaction product by HPLC revealed 2.2 areapercent of 2, 3-dibromo-5, 6-difluoroaniline as a residual intermediate. Reaction was continued under the same conditions for a further 0.5 hours. The catalyst was then removed by filtration. The resulting liquid was subjected to quantitative analysis by HPLC. The yield of 2, 3-difluoroaniline was 93percent. The intermediate 2, 3-dibromo-5, 6-difluoroaniline had been eliminated.

Uses

intermediate for liquid crystal and drugs

Computed Properties

Molecular Weight:129.11
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:129.03900549
Monoisotopic Mass:129.03900549
Topological Polar Surface Area:26
Heavy Atom Count:9
Complexity:97.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2,3-Difluoroaniline

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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5 YRS

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2,3-Difluoroaniline

CAS No.: 4519-40-8

Content: 99.00%

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Hefei Heyu Chemical New Materials Co., Ltd Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of 13-Dimethyladamantane,1-Bromo-35-dimethyladamantane,perhydroacenaphthylene,4-[1,1-bis(4-hydroxyphenyl)ethyl]phenol,CYCLOBUTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER, TRANS

2,3-Difluoroaniline 4519-40-8

CAS No.: 4519-40-8

Content: 99%

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