5-Chlorobenzimidazole

General procedure: TUD (20 mmol) was added in batches to a solution of substituted 2‑nitroanilines (5 mmol) and NaOH (20 mmol) in H2O (15 mL) and EtOH (5 mL) at 70 °C. The reaction mixture was stirred for a certain period of time as required to complete the reaction (monitored byTLC). After cooling, 10percent NaOH solutions were added until pH = 9–10, the precipitated solid was filtered off and washed with water to obtain crude product. The crude product was recrystallised from water to give a white solid. The physical and spectra data of the compounds 2a–h were as follows.General procedure: Adding an appropriate amount of water to the microwave reactor, 1 mmol of benzamidine and 0.2 mmol of cesium carbonate were reacted at a fixed power of 120 W and 50 C for 10 min, extracted with ethyl acetate and concentrated under reduced pressure.Product silica gel column separation, A white solid was obtained in a yield of 99%.General procedure: To a 10 mL three-necked round bottle was added 1a (0·54 g, 5 mmol), imidazole hydrochloride (0.09 g, 0.5 mmol) and N, N-dimethylformamide (2 mL). The resulting solution was warmed to 120 C and the reaction was stirred at this temperature. TLC was applied to the plate. When the reaction was completed, 25 mL of water was added, and the mixture was extracted twice with 25 mL of ethyl acetate. The combined organic layers were washed sequentially with H2O (50 mL) then brine. It was then dried over anhydrous Na2SO4, filtered and evaporated. The residue was purified by silica gel column chromatography. Recrystallization from petroleum ether and ethyl acetate or petroleum ether / EA afforded the desired product.In a 150 mL round bottom flask was added intermediate VI-7 5-chlorobenzimidazole (0.31 g, 2.04 mmol).After stirring potassium carbonate as a base (0.30 g, 2.20 mmol) and acetonitrile as a solvent at 50 C for 40 minutes, After cooling to room temperature, intermediate V (0.43 g, 1.70 mmol) was added and the mixture was warmed to 75 C and the mixture was traced to the end of the reaction.After further concentration, extraction, column chromatography separation, drying and the like, the intermediate X-7 (0.51 g) is obtained, the yield is 73.7%;Light pink solid,

Molecular Weight:152.58
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:152.0141259
Monoisotopic Mass:152.0141259
Topological Polar Surface Area:28.7
Heavy Atom Count:10
Complexity:129
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes