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Puromycin

Puromycin structure

CAS No:
53-79-2
Formula:
C22H29N7O5
Chemical Name:
Puromycin
Synonyms:
Adenosine,3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-;Adenosine,3′-(α-amino-p-methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyl-,L-;Adenosine,3′-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-,(S)-;3′-[[(2S)-2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyladenosine;1-MM;P 638;3123L;Puromycin;Stylomycin;Achromycin (purine derivative);β-D-Ribofuranoside,6-(dimethylamino)-9H-purine-9 3-deoxy-3-[(4-methoxy-L-phenylalanyl)amino]-;Stillomycin;Achromycin;CL 13900
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

Puromycin Basic Attributes

Molecular Weight：

471.51

Exact Mass：

471.51

EC Number：

200-387-8

Characteristics

PSA：

161

XLogP3：

0.93

Appearance：

Puromycin dihydrochloride is a white powder. (NTP, 1992)

Density：

1.5±0.1 g/cm3

Melting Point：

175.5-177 °C

Refractive Index：

1.701

Water Solubility：

soluble in water (50 mg/ml at 20°C).

Toxicity：

Oral-Mouse LD50: 20 mg/kg; Abdominal cavity-mouse LD50: 25 mg/kg

Flammability characteristics：

Open flame is flammable; burning releases toxic nitrogen oxide fumes

Specific rotation：

D25 -11° (ethanol)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

RTECS Number：

AU7350000

Storage features：

Treasury is ventilated at low temperature and dry; stored separately from oxidants and food additives

Toxicity

Toxicity class：

most toxic

Puromycin Use and Manufacturing

Puromycin is a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypanosomal agent with antibiotic activity. Puromycin is non-selective, inhibiting RNA by blocking ribosomal translation. Puromycin is used in cell biology to select mammalian cell lines that have been transformed by vectors that express puromycin-N-acetyl-transferase.