N-Hydroxy-2-aminofluorene

197.237

197.23

61M94X4V24

DTXSID50201045

2928000090

32.3

3.3

1.0957 (rough estimate)

211.3 °C @ Solvent: Toluene

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)|Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. (See all compounds classified as Carcinogens.)

EVIDENCE FOR THE DIRECT ACETYLATION OF N-HYDROXY-2-AMINOFLUORENE CATALYZED BY RAT LIVER CYTOSOL HAS BEEN OBTAINED.|THE O-GLUCURONIDE OF N-HYDROXY-2-FLUORENAMINE IS A MUCH MORE REACTIVE ELECTROPHILE THAN ITS ACETYLATED DERIVATIVE &, IF FORMED IN VIVO, COULD BE AN IMPORTANT REACTIVE FORM /IN NEOPLASM INDUCTION/.|N-HYDROXY-2-FLUORENAMINE, AN ELECTROPHILIC REAGENT AT ACIDIC PH'S, HAS LITTLE, IF ANY, REACTIVITY AT NEUTRALITY. EARLIER REPORTS ON THE APPARENT REACTIVITY OF THIS HYDROXYLAMINE ON INCUBATION WITH LIVER PREPARATIONS ... APPEAR TO BE A CONSEQUENCE OF N-ACETOXY-2-FLUORENAMINE FORMATION. THIS VERY REACTIVE ESTER IS FORMED BY THE ENZYMATIC TRANSFER OF THE N-ACETYL GROUP OF N-HYDROXY-2-FLUROENYLACETAMIDE TO THE OXYGEN OF THE HYDROXYLAMINE. THIS REACTION IS OF ... INTEREST SINCE STRONGLY REACTIVE ACETIC ACID ESTERS OF SEVERAL OTHER CARCINOGENIC AROMATIC HYDROXYLAMINES ARE FORMED BY THE SAME, OR SIMILAR, ENZYME SYSTEMS & SINCE A NUMBER OF TISSUES CATALYZE THE REACTION.|KINETIC STUDIES OF THE HYDROLYSIS REACTION SHOWED THAT IT OCCURS ALREADY AT A MEASURABLE RATE AT PH 9.5 & 37 °C. THE REACTION IS CATALYZED BY MAGNESIUM AND MANGANESE IONS & BY ALKALINE PHOSPHATASE FROM ESCHERICHIA COLI.|N-hydroxy-2-aminofluorene has known human metabolites that include N-hydroxy-2-aminofluorene, O-acetyl.

N-2-hydroxyaminofluorene